Transcription profiling of mouse broncheolar lavage cells to diagnoses of acute lung rejection by gene expression profiling

ABSTRACT: Acute lung rejection is a risk factor for chronic rejection, jeopardizing the long-term survival of lung transplant recipients. At present, acute rejection is diagnosed by transbronchial lung biopsies, which are invasive, expensive, and subject to significant sampling error. In this study, we sought to identify groups of genes whose collective expression in BAL cells best classifies acute rejection versus no-rejection. BAL samples were analyzed from 32 unique subjects whose concurrent histology showed acute rejection (n=14) or no rejection (n=18). Global BAL cell gene expression was measured using Affymetrix U133A microarrays. The nearest shrunken centroid method with 10-fold cross validation was used to define the classification model. 250 runs of the algorithm were performed to determ

ORGANISM(S): Homo sapiens

SUBMITTER: Jeff Lande 

PROVIDER: E-GEOD-6095 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress