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MetabolomicsAdaptive Evolution Reveals Mechanisms of Isobutanol Tolerance in Zymomonas mobilis

Isobutanol production has been demonstrated in E. coli and Z. mobilis using heterologous pathways, with titers reaching up to 60% of the theoretical yield under optimized conditions. However, these results often depend on impractical setups, such as continuous product extraction, oxygenation, or ...

2026-03-18 | MTBLS14081 | MetaboLights
MetabolomicsOsh2 mediates Candida resistance to miltefosine by regulating zymosterol transport
Miltefosine has been identified for its antifungal properties, yet the mechanisms underlying its action and the development of resistance remain unclear. In this study, we induced drug resistance in various Candida species through concentration gradient exposure, successfully obtaining a miltefosine...
2025-07-03 | MTBLS12270 | MetaboLights
MetabolomicsStress-induced enrichment of Pseudomonas sp. stimulates the adaptive response of Auxenochlorella pyrenoidosa and antibiotic-resistant proliferation

The phycosphere is an important ecological niche for bacteria and antibiotic resistance genes (ARGs). However, whether and how the interaction between microalgae and bacteria changed, and its further effect on the transmission of ARGs under pollutant stress remains enigmatic. Here, Auxenochlorell...

2025-09-26 | MTBLS11371 | MetaboLights
MetabolomicsGut microbiota within-host evolution enforces colonization resistance against enteric infection

Limited resource availability in the gut promotes competitive interactions between bacteria, which drive adaptive within-host evolution. While the role of bacterial adaptive evolution of bacterial communities has been extensively studied, its functional implications for host physiology remain unk...

2026-08-03 | MTBLS10327 | MetaboLights
MetabolomicsIntegrative transcriptomic, metabolomic, and physiological analyses reveal the root adaptive mechanisms of common vetch (Vicia sativa L.) under drought stress
Drought is a major abiotic stress that limits the productivity and ecological adaptability of leguminous forage crops. As the primary organs that sense soil water deficits, roots play an essential role in plant adaptation to drought. Common vetch (Vicia sativa L.) is an important annual leguminous f...
2026-07-27 | MTBLS15164 | MetaboLights
Genomicsecoli adaptive resistance
Adaptive resistance and growth of Escherichia coli bacteria in an antibiotic gradient
PRJEB7521 | ENA
ProteomicsAdaptive resistance to MEK and PI3K inhibition in pancreatic cancer cells
Pancreatic cancer is one of the most lethal cancers. Preclinical studies have shown adaptive resistance to Raf/MEK/ERK and PI3K/Akt pathway inhibition. We identify common protein expression alterations associated with adaptive resistance to MEK and PI3K kinase inhibition in KRas-mutant pancreatic ca...
ORGANISM(S): Homo sapiens (Human) 
2025-03-10 | PXD039692 | Pride
Pi3k inhibition Proteomics Adaptive resistance Mek inhibition Resistance Pancreatic cancer 
MetabolomicsOGFOD1 enables AML chemo- and nutrient stress resistance by regulating protein synthesis

Acute Myeloid Leukemia (AML) commonly relapses after initial chemotherapy response. We assessed metabolic adaptations in chemoresistant cells in vivo before overt relapse, identifying altered branched-chain amino acid (BCAA) levels in patient-derived xenografts (PDX) and immunophenotypically iden...

2025-07-19 | MTBLS10255 | MetaboLights
ProteomicsAdaptive resistance to Afatinib in non-small cell lung cancer cells in attenuated by Ca2+ depletion
Targeted therapies against oncogenic receptor tyrosine kinases are showing promising results in the clinic. However, despite the initial response, most patients become resistant. The majority of research regarding resistance has been focused on acquired resistance occurring after an extensive time o...
ORGANISM(S): Homo sapiens (Human) 
2018-10-02 | PXD008454 | Pride
Egfr  adaptive resistance  non-small lung cancer  tyrosine kinase inhibitors  calcium signaling 
GenomicsAdaptive anoikis resistance promotes ovarian cancer metastasis
Adaptive anoikis resistance promotes ovarian cancer metastasis
PRJNA1008671 | ENA
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