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UnknownHost adaptive mutations in the 2009 H1N1 pandemic influenza A virus PA gene regulate translation efficiency of viral mRNAs via GRSF1
Not available
S-EPMC9576711 | biostudies-literature
TranscriptomicsIdentification of Adaptive mutations in the influenza A virus non-structural 1 gene that increase cytoplasmic localization and differentially regulate host gene expression
The NS1 protein of influenza A virus (IAV) is a multifunctional virulence factor. Mouse adaptive mutations in the NS1 protein of the human isolate A/Hong Kong/1/1968(H3N2) (HK) have been previously reported to increase virulence, viral fitness, and interferon antagonism, but differ in binding to pos...
ORGANISM(S): Mus musculus 
2013-06-22 | E-GEOD-48217 | biostudies-arrayexpress
TranscriptomicsIdentification of Adaptive mutations in the influenza A virus non-structural 1 gene that increase cytoplasmic localization and differentially regulate host gene expression
The NS1 protein of influenza A virus (IAV) is a multifunctional virulence factor. Mouse adaptive mutations in the NS1 protein of the human isolate A/Hong Kong/1/1968(H3N2) (HK) have been previously reported to increase virulence, viral fitness, and interferon antagonism, but differ in binding to pos...
ORGANISM(S): Mus musculus 
2013-06-22 | GSE48217 | GEO
TranscriptomicsRNA-seq time-course of Calu-3 cells infected with SARS-CoV-2 early-lineage and Alpha variant viruses
Emergence of SARS-CoV-2 variants of concern (VOCs), including the globally successful Alpha (B.1.1.7) variant, suggests viral adaptation to enhance human-to-human transmission. Although much effort has focused on characterisation of spike changes, Alpha mutations outside spike likely contribute to a...
ORGANISM(S): Homo sapiens 
2021-12-31 | E-MTAB-11275 | biostudies-arrayexpress
UnknownFunctional Characterization of Adaptive Mutations during the West African Ebola Virus Outbreak.
Not available
S-EPMC5215343 | biostudies-literature
UnknownPandemic influenza A viruses escape from restriction by human MxA through adaptive mutations in the nucleoprotein.
Not available
S-EPMC3610643 | biostudies-literature
UnknownAdaptive Mutations That Occurred during Circulation in Humans of H1N1 Influenza Virus in the 2009 Pandemic Enhance Virulence in Mice.
Not available
S-EPMC4473582 | biostudies-literature
UnknownFunctional mutations of SARS-CoV-2: implications to viral transmission, pathogenicity and immune escape.
Not available
S-EPMC9337262 | biostudies-literature
TranscriptomicsMultiomics study to identify virulence factors of Rickettsia prowazekii revealed its adaptive mutation capabilities
We identified four virulence phenotypes of Rickettsia prowazekii (the deadly agent of epidemic typhus) that are associated with the upregulation of antiapoptotic genes (virulent strain) or the Interferon I pathway (avirulent). Transcriptional and proteomic analyses of R. prowazekii linked surface pr...
ORGANISM(S): Rickettsia prowazekii 
2010-06-05 | E-GEOD-15630 | biostudies-arrayexpress
UnknownAdaptive mutations promote hepatitis C virus assembly by accelerating core translocation to the endoplasmic reticulum.
Not available
S-EPMC7949066 | biostudies-literature
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