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TranscriptomicsTranscription profiling of Bordetella bronchiseptica strains 253 and RB50 to investigate adenylate cyclase toxin (ACT) expression
Bordetella bronchiseptica is a gram-negative respiratory pathogen that causes a diverse spectrum of respiratory disease in a wide-range of hosts. We sought to determine if strains of B. bronchiseptica differed in virulence using the mouse model of infection. Mean lethal doses (LD50) of different B. ...
ORGANISM(S): Bordetella bronchiseptica 
2007-10-01 | E-MEXP-1203 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of Bordetella bronchiseptica strains 253 and RB50 to investigate the cya adenylate cyclase toxin (ACT) operon
Bordetella bronchiseptica is a gram-negative respiratory pathogen that causes a diverse spectrum of respiratory disease in a wide-range of hosts. We sought to determine if strains of B. bronchiseptica differed in virulence using the mouse model of infection. Mean lethal doses (LD50) of different B...
ORGANISM(S): Bordetella bronchiseptica 
2007-10-01 | E-MEXP-1205 | biostudies-arrayexpress
TranscriptomicsTranscriptional responses of murine macrophages to the adenylate cyclase toxin of Bordetella pertussis
Three different recombinant forms of CyaA were used to investigate transcriptional responses of murine bone marrow-derived macrophages (BMDMs) using Affymetrix Mouse Genome Genechips. These forms were enzymically active, invasive CyaA, nonenzymically active, invasive CyaA (CyaA*) and non-enzymically...
ORGANISM(S): Mus musculus 
2013-09-22 | E-GEOD-51075 | biostudies-arrayexpress
ProteomicsPhosphoproteomics of cAMP signaling of adenylate cyclase toxin in mouse dendritic cells
The whooping cough agent, Bordetella pertussis, subverts dendritic cell (DCs) functions through powerful immunomodulatory activities of its toxins. Here we focused on the signaling action of the adenylate cyclase toxin (CyaA) that targets myeloid cells expressing the αMβ2 integrin CD11b/CD18 (known ...
ORGANISM(S): Mus musculus (Mouse) 
2017-11-29 | PXD004733 | Pride
Adenylate cyclase toxin Bone marrow-derived dendritic cells Bordetella pertussis Phosphoproteome 
ProteomicsRetargeting from CR3 to the LFA-1 receptor uncovers the adenylyl cyclase enzymetranslocating segment of Bordetella adenylate cyclase toxin
The Bordetella adenylate cyclase toxinhemolysin (CyaA) and the α-hemolysin (HlyA) of Escherichia coli both belong to the family of cytolytic pore-forming Repeats in ToXin (RTX) cytotoxins. HlyA preferentially binds the αLβ2 integrin LFA-1 (CD11a/CD18) of leukocytes and can promiscuously bind and per...
ORGANISM(S): Escherichia coli Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251) 
2020-05-11 | PXD018789 | Pride
Ac domain translocation Fatty acyl Rtx toxin Acylation Acyltransferase Integrin 
UnknownBioengineering of Bordetella pertussis Adenylate Cyclase Toxin for Vaccine Development and Other Biotechnological Purposes.
Not available
S-EPMC7911819 | biostudies-literature
UnknownBioengineering of Bordetella pertussis Adenylate Cyclase Toxin for Antigen-Delivery and Immunotherapy.
Not available
S-EPMC6070788 | biostudies-literature
UnknownVibrio vulnificus biotype 3 multifunctional autoprocessing RTX toxin is an adenylate cyclase toxin essential for virulence in mice.
Not available
S-EPMC3993422 | biostudies-literature
UnknownBordetella pertussis Adenylate Cyclase Toxin Disrupts Functional Integrity of Bronchial Epithelial Layers.
Not available
S-EPMC5820963 | biostudies-literature
UnknownAdenylate Cyclase Toxin promotes bacterial internalisation into non phagocytic cells.
Not available
S-EPMC4642564 | biostudies-literature
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