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ProteomicsProximity proteomics provides a new resource for exploring the function of Afadin and the complexity of cell-cell adherens junctions
Afadin and its Drosophila homolog Canoe are key components of the network of proteins that help link cell-cell adherens junctions to the actomyosin cytoskeleton. They stabilize this connection as force is generated to drive cell shape change and migration during embryonic morphogenesis, organogenes...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2025-01-20 | PXD056971 | Pride
Bioid Afadin Cell-cell adherens junctions 
TranscriptomicsTranscription profiling of mouse VE-cadherin null cell line vs contrik
In order to identify genes regulated by VE-cadherin expression, we compared a mouse VE-cadherin null cell line (VEC null) with the same line reconstituted with VE-cadherin wild type cDNA (VEC positive). The morphological and functional properties of these cell lines were described previously [Lampug...
ORGANISM(S): Mus musculus 
2008-10-20 | E-GEOD-11674 | biostudies-arrayexpress
ProteomicsVE-cadherin interaction proteomics identifies ARVCF as a key stabilizer of endothelial adherens junctions
The endothelial cells lining the vascular wall maintain a selective barrier between blood and tissue. Structural connections between these endothelial cells are formed through vascular endothelial (VE)-cadherin-based adherens junctions. The extracellular domain of VE-cadherin forms homotypic bonds b...
ORGANISM(S): Homo sapiens (Human) 
2026-03-18 | PXD068012 | Pride
Ve-cadherin interaction proteomics identifies arvcf as a key stabilizer of endothelial adherens junctions 
UnknownTRIP6 is required for tension at adherens junctions.
Not available
S-EPMC7970510 | biostudies-literature
GenomicsM-cadherin regulates the formation of adherens junctions and secondary myofibers during fetal myogenesis to determine adult myofiber number and muscle mass
M-cadherin regulates the formation of adherens junctions and secondary myofibers during fetal myogenesis to determine adult myofiber number and muscle mass
PRJNA1400065 | ENA
ProteomicsThe colitis risk gene C1orf106 (ROCS) regulates epithelial adherens junction stability
Mohanan V, Nakata T, Desch N, L�vesque C, Boroughs A, Guzman G, Cao Z, Creasey E, Yao J, Boucher G, Charron G, Bhan AK, Schenone M, Carr SA, Reinecker HC, Daly MJ, Rioux JD, Lassen KG, Xavier RJ. Science 2018. Single nucleotide polymorphisms in C1orf106 are associated with increased risk of inflamma...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-01-16 | MSV000081941 | MassIVE
ProteomicsThe Influences of ApoE Isoforms on Endothelial Adherens Junctions and Actin Cytoskeleton Responding to mCRP
Monomeric C-reactive protein (mCRP) plays a role in cerebrovascular damage mediated by apolipoprotein E4 (ApoE4) in Alzheimer's disease (AD) pathogenesis. Using proteomic profilings, we found altered cytoskeleton proteins in the microvasculature of AD brains, including increased levels of hyperphosp...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-05-06 | PXD051529 | Pride
Apolipoprotein e (apoe)  monomeric c-reactive protein (mcrp)  lim domain and actin binding 1 (lima1)  cd31 and pcd31  cerebrovascular  endothelia  f-actin  alzheimer’s disease (ad) 
TranscriptomicsSmoking-induced Disarray of the Apical Junctional Complex Gene Expression Architecture in the Human Airway Epithelium
The apical junctional complex (AJC), composed of tight junctions and adherens junctions, is essential for maintaining epithelial barrier function. Since cigarette smoking and chronic obstructive pulmonary disease (COPD), the major smoking-induced disease, are both associated with increased lung epit...
ORGANISM(S): Homo sapiens 
2011-06-27 | E-GEOD-20257 | biostudies-arrayexpress
UnknownMyosin-dependent remodeling of adherens junctions protects junctions from Snail-dependent disassembly.
Not available
S-EPMC4738385 | biostudies-literature
TranscriptomicsM-cadherin regulates the formation of adherens junctions and secondary myofibers during fetal myogenesis to determine adult myofiber number and muscle mass
Cadherin-mediated adhesion of skeletal muscle stem cells within their niche is necessary for normal adult muscle maintenance and regeneration; however, the role of cadherins in regulating muscle development and growth has not yet been elucidated. Here, we show that M-cadherin protein is localized to...
ORGANISM(S): Mus musculus 
2026-01-13 | GSE315987 | GEO
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