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ProteomicsProximity proteomics provides a new resource for exploring the function of Afadin and the complexity of cell-cell adherens junctions
Afadin and its Drosophila homolog Canoe are key components of the network of proteins that help link cell-cell adherens junctions to the actomyosin cytoskeleton. They stabilize this connection as force is generated to drive cell shape change and migration during embryonic morphogenesis, organogenes...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2025-01-20 | PXD056971 | Pride
Bioid Afadin Cell-cell adherens junctions 
GenomicsCold-induction of Afadin in Brown Fat supports its thermogenic capacity
Cold-induction of Afadin in Brown Fat supports its thermogenic capacity
PRJNA614482 | ENA
ProteomicsProximity proteomics identifies PAK4 as a component of Afadin–Nectin junctions.
Human PAK4 is an ubiquitously expressed p21-activated kinase which acts downstream of Cdc42. Since PAK4 is demonstrably enriched in cell-cell junctions, we probed the local protein environment around the kinase with a view to understanding its location and substrates. In U2OS cells expressing PAK4-B...
ORGANISM(S): Homo sapiens (Human) 
2021-11-30 | PXD024464 | Pride
Lzts2 Pak4 Cdc42 Bioid Epithelial cells Protein kinase Cell junctions 
TranscriptomicsCold-induction of Afadin in Brown Fat supports its thermogenic capacity
Transcriptomic analysis of brown fat from fat-specific Afadin depleted mice either at thermoneutrality or after 6 houts of cold exposure (5 degree celsius)
ORGANISM(S): Mus musculus 
2021-05-12 | GSE147392 | GEO
UnknownAfadin cooperates with Claudin-2 to promote breast cancer metastasis.
Not available
S-EPMC6362814 | biostudies-literature
UnknownCold-induction of afadin in brown fat supports its thermogenic capacity.
Not available
S-EPMC8105362 | biostudies-literature
UnknownInvolvement of afadin in barrier function and homeostasis of mouse intestinal epithelia.
Not available
S-EPMC3115770 | biostudies-literature
UnknownRap1 regulates lumen continuity via Afadin in renal epithelia.
Not available
S-EPMC10460627 | biostudies-literature
UnknownAfadin is a scaffold protein repressing insulin action via HDAC6 in adipose tissue.
Not available
S-EPMC6680131 | biostudies-literature
UnknownA short splicing isoform of afadin suppresses the cortical axon branching in a dominant-negative manner.
Not available
S-EPMC4436838 | biostudies-literature
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