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TranscriptomicsTransport of influenza A virus neuraminidase to host cell surface and virus replication are regulated by ARHGAP21 and Cdc42
Influenza virus neuraminidase (NA), a type II transmembrane glycoprotein, is transported to the virus assembly site at the plasma membrane and is a major viral envelope component that plays a critical role in the release of progeny virions and in determination of host range restriction. Although sig...
ORGANISM(S): Homo sapiens 
2012-04-03 | E-GEOD-32878 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Cdc42 knockout murine cytotoxic T lymphocytes
This project explores the effects of Cdc42 gene-knock in effector cytotoxic T lymphocytes (CTLs). Effector CTLs were differentiated from OTI TCR transgenic mice for 5 days in vitro, then nucleofected with CRISPR/Cas9 RNPs targeting Cdc42 or non-targeting sequence.
ORGANISM(S): Mus musculus 
2025-07-29 | E-MTAB-14519 | biostudies-arrayexpress
ProteomicsA Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia...
3xFLAG-IPs from HEK293T cell lysates expressing 3xFLAG-bait or 3xFLAG-control. Trypsin Digestion
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-04-09 | MSV000079100 | MassIVE
TranscriptomicsStudies of target genes for signal transduction pathways (using a Ras1-, a Cdc42- and a Gap1-mutant) in the basidiomycete Schizophyllum commune.
Transcriptome changes associated with signal transduction mutants were analysed in order to identify targets of the distinct pathways of Ras1, Cdc42 and Gap1. Two monokaryons (12-43 and 4-39), a dikaryon (W22 x 12-43), a constitutive active Ras1 mutant (T2G12V, monokaryon), a Cdc42 mutant (G12V, mon...
ORGANISM(S): Schizophyllum commune 
2013-02-01 | E-GEOD-43965 | biostudies-arrayexpress
ProteomicsCdc42 controls DC-maturation - Cdc42-dependent actin dynamics controls maturation and secretory activity of dendritic cells
Cell division cycle 42 (Cdc42) is a member of the Rho GTPase family and has pivotal functions in actin organization, cell migration and proliferation. Cdc42 has been shown to regulate antigen (Ag)-uptake in immature dendritic cells (DC) and controls their migration from tissues to lymph nodes. Previ...
ORGANISM(S): Mus musculus (Mouse) 
2015-10-12 | PXD001934 | Pride
Lc-ms Cdc42 Label-free Dendritic cells 
ProteomicsA ubiquitin-based effector-to-inhibitor switch coordinates brain, craniofacial, and skin development
The molecular mechanisms that coordinate patterning of the embryonic ectoderm into spatially distinct lineages to form the nervous system, epidermis, and craniofacial structures are unclear. Here, biochemical disease-variant profiling reveals a posttranslational pathway that drives early ectodermal ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-11-14 | MSV000090711 | MassIVE
ProteomicsTranscriptional adaptation after deletion of Cdc42 in primary T cells
Cdc42 is a Rho family GTPase known for its central role in cell polarity and cytoskeletal regulation. To understand the role of Cdc42 in polarised secretion from cytotoxic T lymphocytes (CTLs) we used CRISPR/Cas9 gene deletion. While Cdc42-deleted CTLs initially showed reduced secretion for up to tw...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-08 | PXD063348 | Pride
T cell Rho gtpase Crispr/cas9 Transcriptional adaptation Cdc42 
ProteomicsThe specific localization and function of Cdc42 isoforms
Cdc42 is a small GTPase protein whose role in polarity is widely studied. However, in vertebrates there exist 2 isoforms arising due to alternative splicing. The function and localization of these have not been studied with respect to cell polarity and cell migration. We therefore perform a mass spe...
ORGANISM(S): Homo sapiens (Human) 
2024-01-23 | PXD017477 | Pride
Golgi Isoforms Sub-cellular localization Cdc42 
GenomicsCDC42 inhibitors regulate genes involved in skin vasculaization
CDC42 inhibitors regulate genes involved in skin vasculaization
PRJNA1269543 | ENA
GenomicsGene expression profiles of Treg cells lacking Cdc42 GTPase
Gene expression profiles of Treg cells lacking Cdc42 GTPase
PRJNA753464 | ENA
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