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TranscriptomicsSingle-molecule, full-length transcript isoform sequencing reveals disease-associated RNA isoforms
Alternative splicing generates differing RNA isoforms that govern phenotypic complexity of eukaryotes. Its malfunction underlies many diseases, including cancer and cardiovascular diseases. Comparative analysis of RNA isoforms at the genome-wide scale has been difficult. Here, we established an expe...
ORGANISM(S): Homo sapiens 
2021-06-16 | E-MTAB-7334 | biostudies-arrayexpress
TranscriptomicsDifferential roles of Sall4 isoforms in ES cell pluripotency
This SuperSeries is composed of the following subset Series: GSE21054: Differential roles of Sall4 isoforms in ES cell pluripotency: expression GSE21055: Differential Role of Sall4 isoforms in ES cell pluripotency: ChIP-chip Refer to individual Series
ORGANISM(S): Mus musculus 
2010-09-13 | E-GEOD-21056 | biostudies-arrayexpress
TranscriptomicsOncogenic potential of RAS isoforms in melanocytes
We compared the transformation efficiencies of mutant NRAS and KRAS in immortal, non-transformed Ink4a/Arf-deficient melanocytes. NRAS mutation leads to increased cellular proliferation and is potently tumorigenic. In contrast, KRAS mutation does not enhance melanocyte proliferation and is only weak...
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-6194 | biostudies-arrayexpress
ProteomicsPI3Kinase Isoforms in Pancreatic cancer
Pancreatic ductal adenocarcinoma is one of the most lethal cancers, with a 5 year-survival rate below 5%. Lack of curative treatment and failure of targeted therapies urge the need to identify novel efficient therapeutic strategy. Achievement of this goal will be obtained through the identification ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-28 | PXD008410 | Pride
Pi3k signaling pathway isoforms 
TranscriptomicsTunable protein synthesis by transcript isoforms in human cells (Transcript Isoforms in Polysomes sequencing: TrIP-seq)
Eukaryotic genes generate multiple mRNA transcript isoforms though alternative transcription, splicing, and polyadenylation. However, the relationship between human transcript diversity and protein production is complex as each isoform can be translated differently. We fractionated a polysome profil...
ORGANISM(S): Homo sapiens 
2016-01-11 | E-GEOD-69352 | biostudies-arrayexpress
ProteomicsCardiac myofilament isoforms - Identification of cardiac myofilament protein isoforms using multiple mass spectrometry based approaches
Purpose: The identification of protein isoforms in complex biological samples is challenging. We, therefore, used a mass spectrometry (MS) approach to unambiguously identify cardiac myofilament protein isoforms based on the observation of a tryptic peptide consisting of a sequence unique to a partic...
ORGANISM(S): Rattus norvegicus (Rat) 
2014-08-28 | PXD000874 | Pride
Multiple search engines Bioinformatics Cardiomyocyte Sarcomere Protein isoforms Rat cardiac tissue Myofilament proteome Protein sub-isoforms Lc-ms/ms 
ProteomicsThe specific localization and function of Cdc42 isoforms
Cdc42 is a small GTPase protein whose role in polarity is widely studied. However, in vertebrates there exist 2 isoforms arising due to alternative splicing. The function and localization of these have not been studied with respect to cell polarity and cell migration. We therefore perform a mass spe...
ORGANISM(S): Homo sapiens (Human) 
2024-01-23 | PXD017477 | Pride
Golgi Isoforms Sub-cellular localization Cdc42 
TranscriptomicsDiscovery of novel isoforms of Huntingtin reveals a new hominid-specific exon
Huntington’s disease (HD) is a devastating neurological disorder that is caused by an expansion of the poly-Q tract in exon 1 of the Huntingtin gene (HTT). HTT is an evolutionarily conserved and ubiquitously expressed protein that has been linked to a variety of functions including transcriptional r...
ORGANISM(S): Homo sapiens 
2015-06-10 | E-GEOD-66769 | biostudies-arrayexpress
Proteomicsbinding specificity of Native Odorant-Binding Protein isoforms is driven by phosphorylation and O-N-acetylglucosamiylation in the pig (sus scrofa)
In pig, phosphorylation drives binding specificity of recombinant OBP (stricto sensu, referred as OBP in this text) isoforms (Brimau et al., 2010) that are not O-GlcNAcylated, contrary to native OBP, purified from nasal tissue (Nagnan-Le Meillour et al., 2014). In order to precise the role of both P...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2019-02-15 | PXD011371 | Pride
Cid-nano-lc-ms/ms Odorant-binding protein Fluorescence spectroscopy Pheromone O-glcnac Phosphorylation 
ProteomicsLocalization of functionally distinct CDC42 isoforms in neurons requires alternative 3'UTR usage
The proper subcellular localization of RNAs and local translational regulation is crucial in highly compartmentalized cells, such as neurons. RNA localization is mediated by specific cis-regulatory elements usually found in mRNA 3'UTRs. Therefore, processes that generate alternative 3'UTRs – alterna...
ORGANISM(S): Mus musculus (Mouse) 
2018-12-07 | PXD011518 | Pride
Cdc42 Localization Silac Isoforms 
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