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ProteomicsCharacterization of the PAK4 interactome by quantitative mass spectrometry
p21-activated kinase 4 (PAK4) is a serine/threonine kinase critical during development and with a proposed role in cancer and related cellular processes, including cell proliferation, survival and migration. However, while a limited number of PAK4-interacting proteins have been identified, the PAK4 ...
ORGANISM(S): Homo sapiens (Human) 
2018-10-27 | PXD004086 | Pride
Ms/ms Pull-down Protein-protein interactions Pak4 
ProteomicsProximity proteomics identifies PAK4 as a component of Afadin–Nectin junctions.
Human PAK4 is an ubiquitously expressed p21-activated kinase which acts downstream of Cdc42. Since PAK4 is demonstrably enriched in cell-cell junctions, we probed the local protein environment around the kinase with a view to understanding its location and substrates. In U2OS cells expressing PAK4-B...
ORGANISM(S): Homo sapiens (Human) 
2021-11-30 | PXD024464 | Pride
Lzts2 Pak4 Cdc42 Bioid Epithelial cells Protein kinase Cell junctions 
ProteomicsDifferential roles and regulation of the protein kinases PAK4, PAK5 and PAK6 in melanoma cells
The protein kinases PAK4, PAK5 and PAK6 comprise a family of ohnologues. In multiple cancers including melanomas PAK5 most frequently carries non‐synonymous mutations; PAK6 and PAK4 have fewer; and PAK4 is often amplified. To help interpret these genomic data, initially we compared the cellular regu...
ORGANISM(S): Homo sapiens (Human) 
2022-09-01 | PXD035415 | Pride
Pak5 (also known as pak7 Pak4 Pak6 Signalling networks 14‐3‐3 Melanoma Ohnologue/ohnolog 
GenomicsEffect of Pak4 deficiency on transcriptome in liver of mice
Effect of Pak4 deficiency on transcriptome in liver of mice
PRJNA827174 | ENA
GenomicsPAK4 suppresses RELB to prevent senescence-like growth arrest in breast cancer
PAK4 suppresses RELB to prevent senescence-like growth arrest in breast cancer
PRJNA449083 | ENA
GenomicsEffect of Pak4 ablation on transcriptome in liver of fasted mice
Effect of Pak4 ablation on transcriptome in liver of fasted mice
PRJNA885417 | ENA
GenomicsEffect of Pak4 deficiency on transcriptomic profile in eWAT of mice
Effect of Pak4 deficiency on transcriptomic profile in eWAT of mice
PRJNA887050 | ENA
GenomicsEffects of PAK4 deficiency on the transcriptome of hepatic stellate cells
Effects of PAK4 deficiency on the transcriptome of hepatic stellate cells
PRJNA1332601 | ENA
GenomicsEffects of PAK4 knockdown on gene expression in glioblastoma-associated endothelial cells
Effects of PAK4 knockdown on gene expression in glioblastoma-associated endothelial cells
PRJNA645173 | ENA
GenomicsGenome-wide transcriptome analysis of PAK4 inhibition/knockdown in human bladder cancer cell line VMCUB1
Genome-wide transcriptome analysis of PAK4 inhibition/knockdown in human bladder cancer cell line VMCUB1
PRJNA540285 | ENA
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