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ProteomicsDifferential roles and regulation of the protein kinases PAK4, PAK5 and PAK6 in melanoma cells
The protein kinases PAK4, PAK5 and PAK6 comprise a family of ohnologues. In multiple cancers including melanomas PAK5 most frequently carries non‐synonymous mutations; PAK6 and PAK4 have fewer; and PAK4 is often amplified. To help interpret these genomic data, initially we compared the cellular regu...
ORGANISM(S): Homo sapiens (Human) 
2022-09-01 | PXD035415 | Pride
Pak5 (also known as pak7 Pak4 Pak6 Signalling networks 14‐3‐3 Melanoma Ohnologue/ohnolog 
ProteomicsPAK6-mediated phosphorylation of PPP2R2C regulates LRRK2-PP2A complex formation without affecting PP2A activity.
Mutations in leucine rich repeat kinase 2 (LRRK2) are a common cause of inherited and sporadic Parkinson’s disease (PD) and previous work suggests that dephosphorylation of LRRK2 at a cluster of heterologous phosphosites is associated to disease. We have previously reported subunits of the PP1 and P...
ORGANISM(S): Homo sapiens (Human) 
2023-12-06 | PXD044933 | Pride
Dephosphorylation Pak6 Lrrk2 Pp2a Phosphorylation Ppp2r2c Parkinson’s disease 
UnknownA PAK6-IQGAP1 complex promotes disassembly of cell-cell adhesions.
Not available
S-EPMC4059965 | biostudies-literature
UnknownPAK6-mediated phosphorylation of PPP2R2C regulates LRRK2-PP2A complex formation.
Not available
S-EPMC10759229 | biostudies-literature
UnknownSubstrate and inhibitor specificity of the type II p21-activated kinase, PAK6.
Not available
S-EPMC3810134 | biostudies-literature
UnknownPAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2.
Not available
S-EPMC5735978 | biostudies-literature
UnknownPAK6 rescues pathogenic LRRK2-mediated ciliogenesis and centrosomal cohesion defects in a mutation-specific manner.
Not available
S-EPMC11487180 | biostudies-literature
UnknownDNMT1 modulates interneuron morphology by regulating Pak6 expression through crosstalk with histone modifications.
Not available
S-EPMC6140805 | biostudies-literature
UnknownUrinary exosome proteins PAK6 and EGFR as noninvasive diagnostic biomarkers of diabetic nephropathy.
Not available
S-EPMC10548700 | biostudies-literature
UnknownPAK6 promotes homologous-recombination to enhance chemoresistance to oxaliplatin through ATR/CHK1 signaling in gastric cancer.
Not available
S-EPMC9334622 | biostudies-literature
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