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ProteomicsPAK6-mediated phosphorylation of PPP2R2C regulates LRRK2-PP2A complex formation without affecting PP2A activity.
Mutations in leucine rich repeat kinase 2 (LRRK2) are a common cause of inherited and sporadic Parkinson’s disease (PD) and previous work suggests that dephosphorylation of LRRK2 at a cluster of heterologous phosphosites is associated to disease. We have previously reported subunits of the PP1 and P...
ORGANISM(S): Homo sapiens (Human) 
2023-12-06 | PXD044933 | Pride
Dephosphorylation Pak6 Lrrk2 Pp2a Phosphorylation Ppp2r2c Parkinson’s disease 
UnknownPAK6-mediated phosphorylation of PPP2R2C regulates LRRK2-PP2A complex formation.
Not available
S-EPMC10759229 | biostudies-literature
UnknownPP2A subunit PPP2R2C is downregulated in the brains of Alzheimer's transgenic mice.
Not available
S-EPMC7202491 | biostudies-literature
UnknownPPP2R2C loss promotes castration-resistance and is associated with increased prostate cancer-specific mortality.
Not available
S-EPMC3687002 | biostudies-literature
TranscriptomicsTargeting neural cell senescence reverses neuropsychiatric disorders
The accumulation of senescent cells behaves as a key driver of several age-related cancers and degenerative diseases of the general population. Whether cellular senescence also contributes to psychiatric diseases is still elusive. We report here the characterization of a zebrafish model of psychiatr...
ORGANISM(S): Danio rerio 
2022-12-22 | GSE151307 | GEO
UnknownA distinct PP2A subunit regulates local protein phosphorylation at the axon initial segment.
Not available
S-EPMC12675759 | biostudies-literature
Methylation profilingGenome-wide DNA methylation profiling in anorexia nervosa discordant identical twins
Up until now, no study has looked specifically at epigenomic landscapes throughout twin samples, discordant for Anorexia nervosa (AN). Our goal was to find evidence to confirm the hypothesis that epigenetic variations play a key role in the aetiology of AN. In this study, we quantified genome-wide p...
ORGANISM(S): Homo sapiens 
2022-01-31 | GSE186766 | GEO
UnknownMEF2A Regulates the MEG3-DIO3 miRNA Mega Cluster-Targeted PP2A Signaling in Bovine Skeletal Myoblast Differentiation.
Not available
S-EPMC6600538 | biostudies-literature
UnknownUnveiling the role of UPF3B in hepatocellular carcinoma: Potential therapeutic target.
Not available
S-EPMC11309952 | biostudies-literature
UnknownProtein phosphatase 2A activators reverse age-related behavioral changes by targeting neural cell senescence.
Not available
S-EPMC10014060 | biostudies-literature
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