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MetabolomicsAdipocyte-specific Zeb1 confers breast cancer progression by triggering the tumor-associated adipose microenvironment remodeling_untargeted metabolites_Lipidomics

Upon penetrating the basement membrane, breast cancer cells directly interact with their surrounding adipose tissue, which forms a unique tumor-associated adipose microenvironment (TAME). However, the underlying mechanism involved in the regulation of lipid metabolic remodeling in the TAME remain...

2025-04-30 | MTBLS12289 | MetaboLights
TranscriptomicsFLASH-seq analysis of adipocyte precursor subpopulations (P1 and P2) isolated from a high-fat diet (HFD) mouse, comparing two sorting strategies: conventional manual gating and ConvexGating
This experiment evaluates whether the gates predicted by the tool ConvexGating improve the isolation of adipocyte precursor subpopulations (P1 and P2) from one high-fat diet (HFD) mouse relative to conventional manual gating. Visceral white adipose tissue (WAT) was chosen as a challenging test case ...
ORGANISM(S): Mus musculus 
2026-07-17 | E-MTAB-17301 | biostudies-arrayexpress
MetabolomicsAdipocyte-derived β-hydroxybutyrate confers metabolic resilience in multiple myeloma by stabilizing IRF4 via NAT10-mediated acetylation

Multiple myeloma (MM) remains an incurable hematologic malignancy despite advances in treatment. While obesity is a well-established risk factor, the underlying metabolic mechanisms by which adipocytes contribute to disease progression remain elusive. Here, we uncover a critical m...

2026-05-07 | MTBLS14445 | MetaboLights
TranscriptomicsmRNA profiling of MEST knockdown in human adipocyte precursor cells at early stage (day 3) of adipocyte differentiation
The Mesoderm-specific transcript homolog protein MEST is a member of the alpha/beta hydrolase fold family that is expressed in adipose tissue, adipocytes as well as their precursor cells. To get an idea about potential functions of MEST in adipocyte development, we knocked down MEST in human Multipo...
ORGANISM(S): Homo sapiens 
2015-06-24 | E-GEOD-63132 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human hMADS cells during adipocyte and osteoblast differentiation
human adipocyte and osteoblast differentiation of hMADS cells
ORGANISM(S): Homo sapiens 
2008-08-08 | E-MARS-10 | biostudies-arrayexpress
GenomicsDual Functions of TAF7L in Adipocyte Differentiation
The diverse transcriptional mechanisms governing cellular differentiation and development of mammalian tissue remains poorly understood. Here we report that TAF7L, a paralogue of TFIID subunit TAF7, is enriched in adipocytes and mouse white fat tissue (WAT). Depletion of TAF7L reduced adipocyte-spec...
ORGANISM(S): Mus musculus 
2013-01-07 | E-GEOD-41937 | biostudies-arrayexpress
UnknownConditional immortalization of primary adipocyte precursor cells.
Not available
S-EPMC4496986 | biostudies-literature
TranscriptomicsAdipocyte Differentiation of Immortalized Human Bone Marrow-derived Stromal Cells is Modulated by microRNA-155, microRNA-221 and microRNA-222
Human bone marrow mesenchymal stromal cells are capable of limited self-renewal and multi-lineage differentiation in vitro. Several studies have demonstrated that microRNAs, post-transcriptional modifiers of protein expression, play crucial roles in the regulation of these complex processes. To gain...
ORGANISM(S): Homo sapiens 
2011-08-22 | E-GEOD-24898 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embryonic stem cell line CGR8 during differentiation to mesenchymal stem cells and then adipocyte precursors
This experiment is part of the FunGenES project (FunGenES - Functional Genomics in Embryonic Stem Cells partially funded by the 6th Framework Programme of the European Union, http://www.fungenes.org). The experiment was conducted at the University Nice Sophia-Antipolis, Nice, France. The aim of this...
ORGANISM(S): Mus musculus 
2009-07-10 | E-TABM-668 | biostudies-arrayexpress
TranscriptomicsEbf2 is a selective marker of brown and beige adipogenic precursor cells (Microarray)
Brown adipocytes, muscle and dorsal dermis descend from precursor cells in the dermomyotome, but the factors that regulate commitment to the brown adipose lineage are unknown. Here, we prospectively isolated and determined the molecular profile of embryonic brown preadipose cells. Brown adipogenic p...
ORGANISM(S): Mus musculus 
2014-09-16 | E-GEOD-60442 | biostudies-arrayexpress
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