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ProteomicsThe AdipoR2 protein recruits an ER-localized fatty acid elongation complex to promote membrane homeostasis
The human AdipoR2 protein and its C. elegans homolog PAQR-2 are multi-pass plasma membrane proteins that protect cells against membrane rigidification. We seek to better understand the mechanisms by which these proteins can promote the synthesis and incorporation of membrane-fluidizing unsaturated f...
ORGANISM(S): Homo sapiens (Human) Caenorhabditis elegans 
2023-07-20 | PXD031395 | Pride
Paqr-2 Phospholipids C.elegans Human Adipor2 
ProteomicsRegulation of membrane fluidity by RNF145-triggered degradation of the lipid hydrolase ADIPOR2
The regulation of membrane lipid composition is critical for cellular homeostasis. Cells are particularly sensitive to phospholipid saturation, with increased saturation causing membrane rigidification and lipotoxicity. How mammalian cells sense membrane lipid composition and reverse fatty acid (FA)...
ORGANISM(S): Homo sapiens (Human) 
2022-08-10 | PXD034835 | Pride
Ap-ms Tmt Oritrap fusion 
GenomicsRNA sequencing of ADIPOR2 knockout HEK293 cells undergone various treatments with palmitic acid
RNA sequencing of ADIPOR2 knockout HEK293 cells undergone various treatments with palmitic acid
PRJNA666670 | ENA
TranscriptomicsRNA sequencing of ADIPOR2 knockout HEK293 cells undergone various treatments with palmitic acid
How cells maintain vital membrane lipid homeostasis while obtaining most of their constituent fatty acids from a varied diet remains largely unknown. Here, we used transcriptomics, lipidomics, growth and respiration assays and membrane property analyses in human HEK293 cells or human umbilical vein ...
ORGANISM(S): Homo sapiens 
2021-01-18 | GSE158834 | GEO
UnknownAssociations of adiponectin receptor 2 (AdipoR2) gene polymorphisms and AdipoR2 protein expression levels with the risk of colorectal cancer: A case-control study.
Not available
S-EPMC5646978 | biostudies-literature
TranscriptomicsSelectively targeting the AdipoR2-CaM-CaMKII-NOS3 axis by SCM-198 as a rapid-acting therapy for advanced acute liver failure
In acute liver failure (ALF), liver regeneration deficiency is frequently observed, which is the leading cause of ALF and has a high mortality rate. If not treated promptly, ALF may lead to the need for a liver transplant due to limited treatment options. Here, we report the discovery of a 4-guanidi...
ORGANISM(S): Mus musculus 
2024-11-09 | GSE240824 | GEO
GenomicsSelectively targeting the AdipoR2-CaM-CaMKII-NOS3 axis by SCM-198 as a rapid-acting therapy for advanced acute liver failure
Selectively targeting the AdipoR2-CaM-CaMKII-NOS3 axis by SCM-198 as a rapid-acting therapy for advanced acute liver failure
PRJNA1005312 | ENA
UnknownAdipoR2 recruits protein interactors to promote fatty acid elongation and membrane fluidity.
Not available
S-EPMC10279913 | biostudies-literature
UnknownRegulation of meiotic telomere dynamics through membrane fluidity promoted by AdipoR2-ELOVL2.
Not available
S-EPMC10940294 | biostudies-literature
UnknownRegulation of membrane fluidity by RNF145-triggered degradation of the lipid hydrolase ADIPOR2.
Not available
S-EPMC9531299 | biostudies-literature
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