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MetabolomicsFSCN1 as a new druggable target in adrenocortical carcinoma

Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with a high risk of relapse and metastatisation. The actin-bundling protein fascin (FSCN1) is overexpressed in aggressive ACC and represents a reliable prognostic indicator. FSCN1 has been shown to synergize with the Rho/Rac GEF VAV2 i...

2023-03-20 | MTBLS6402 | MetaboLights
TranscriptomicsAdrenocortical Carcinoma Gene Expression Profiling [Agilent]
Adrenocortical carcinoma (ACC) is an aggressive endocrine tumor with a poor 5 year survival rate of 10-20%. We used expression profiling to assess the transcriptional changes associated with ACC as compared to normal adrenal glands with the goal of identifying new targets for treatment. Fourteen A...
ORGANISM(S): Homo sapiens 
2013-11-21 | E-GEOD-19775 | biostudies-arrayexpress
ProteomicsEffects of FSCN1 inactivation on protein expression in human adrenocortical cancer cells
Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with a high risk of relapse and metastatisation. The actin-bundling protein fascin (FSCN1) is overexpressed in aggressive ACC and represents a reliable prognostic indicator. FSCN1 has been shown to synergize with the Rho/Rac GEF VAV2 in e...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-11-18 | MSV000090738 | MassIVE
TranscriptomicsAdrenocortical Carcinoma Gene Expression Profiling [Affymetrix]
Background: Adrenocortical carcinoma (ACC) is associated with poor survival rates. The objective of the study was to analyze ACC gene expression profiling data prognostic biomarkers and novel therapeutic targets. Methods: 44 ACC and 4 normal adrenal glands were profiled on Affymetrix U133 Plus 2 ex...
ORGANISM(S): Homo sapiens 
2013-11-21 | E-GEOD-19750 | biostudies-arrayexpress
TranscriptomicsAdrenocortical Carcinoma Gene Expression Profiling
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-11-21 | E-GEOD-19776 | biostudies-arrayexpress
TranscriptomicsDeregulated miRNAs in adrenocortical tumors
We performed miRNA expression profiling in a series of adrenocortical carcinomas, adrenocortical adenomas and normal adreno cortex using a microarray approach. Significant differentially expressed miRNAs among groups were identified using SAM analysis. Agilent microarray platform containing 903 miR...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-22816 | biostudies-arrayexpress
ProteomicsProteomic Profile of Human Benign and Malignant Adrenocortical Neoplasia.
The molecular pathogenesis of adrenocortical diseases, particularly adrenocortical carcinoma (ACC), has advanced considerably in recent years due to the application of high-throughput molecular analysis. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) offers an approach for identifying and...
ORGANISM(S): Homo sapiens (Human) 
2025-12-15 | PXD062822 | Pride
Human adrenal gland Adrenocortical tumors Adrenocortical carcinoma Normal adrenal cortex Adrenocortical adenona Primary macronodular adrenocortical hyperplasia 
TranscriptomicsGene exrpression profiling of childhood adrenocortical tumors
Pediatric adrenocortical tumors (ACT) are rare and often fatal malignancies; little is known regarding their etiology and biology. To provide additional insight into the nature of ACT, we determined the gene expression profiles of 24 pediatric tumors (five adenomas, 18 carcinomas, and one undetermin...
ORGANISM(S): Homo sapiens 
2015-11-25 | E-GEOD-75415 | biostudies-arrayexpress
TranscriptomicsSF-1 and RNF31 knockdown and forskolin treatment
The human adrenocortical carcinoma cell line NCI-H295R treated with siRNA targeting SF-1 or RNF31 with luciferase-targeting siRNA as control. Combined with forskolin treatment.
ORGANISM(S): Homo sapiens 
2012-02-01 | E-MEXP-3259 | biostudies-arrayexpress
TranscriptomicsAnalysis of circulating microRNAs in adrenocortical tumours
Differential diagnosis of adrenocortical adenoma and carcinoma is of pivotal clinical relevance, as the prognosis and clinical management of benign and malignant adrenocortical tumours is entirely different. Circulating microRNAs are promising biomarker candidates of malignancy in several tumours. I...
ORGANISM(S): Homo sapiens 
2013-11-19 | E-GEOD-49674 | biostudies-arrayexpress
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