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TranscriptomicsProcyanidin-induced apoptosis of esophageal adenocarcinoma cells is mediated via stress-activated protein kinase activation of JUN-dependent transcription.
Epidemiologic studies have shown a significant inverse correlation between fruit and vegetable consumption and incidence of esophageal adenocarcinoma. Procyanidins are polymeric flavanols found in many fruits and vegetables, and have been shown to possess anti-carcinogenic/chemopreventive properties...
ORGANISM(S): Homo sapiens 
2011-06-16 | E-MEXP-2993 | biostudies-arrayexpress
TranscriptomicsGene promoter DNA methylation patterns have limited role in orchestrating transcriptional changes in the fetal liver in response to maternal folate depletion during pregnancy.
Early life exposures are critical in fetal programming and may influence function and health in later life. Adequate maternal folate consumption during pregnancy is essential for healthy fetal development and long-term offspring health. The mechanisms underlying fetal programming are poorly underst...
ORGANISM(S): Mus Musculus 
2016-06-14 | E-MTAB-4013 | biostudies-arrayexpress
TranscriptomicsMaternal folate depletion during early development and high fat feeding from weaning elicit similar changes in gene expression, but not in DNA methylation, in adult offspring (Gene expression data)
Scope: The ‘Predictive Adaptive Response’ hypothesis suggests the in utero environment when mismatched with the post-natal environment can influence later life health. Underlying mechanisms are poorly understood, but may involve gene transcription changes, regulated via epigenetic mechanisms. ...
ORGANISM(S): Mus musculus 
2017-05-22 | E-MTAB-4987 | biostudies-arrayexpress
TranscriptomicsMaternal folate depletion during early development and high fat feeding from weaning elicit similar changes in gene expression, but not in DNA methylation, in adult offspring (DNA methylation data)
Abstract Scope: The ‘Predictive Adaptive Response’ hypothesis suggests the in utero environment when mismatched with the post-natal environment can influence later life health. Underlying mechanisms are poorly understood, but may involve gene transcription changes, regulated via epigenetic mech...
ORGANISM(S): Mus musculus 
2017-05-22 | E-MTAB-4990 | biostudies-arrayexpress
TranscriptomicsOrgan-specific gene expression changes in the fetal liver and placenta in response to maternal folate depletion
Growing evidence supports the hypothesis that the in utero environment can have profound implications for fetal development and for offspring health in later life. Current theory suggests that conditions experienced in utero prepare, or ‘programme’, the fetus for its anticipated post-natal environm...
ORGANISM(S): Mus Musculus 
2016-06-14 | E-MTAB-3940 | biostudies-arrayexpress
TranscriptomicsBilberries reduce low-grade inflammation and subacute endotoxemia in individuals with features of metabolic syndrome - microarray/QPCR profiling of dietary effects of bilberries in PBMCs
Obesity and its consequences on cardiometabolic health have been associated to low-grade inflammation. The most diverse source of dietary anti-inflammatory compounds is polyphenols and especially anthocyanins, which are major polyphenols in bilberries (Vaccinium myrtillus). We investigated the effec...
ORGANISM(S): Homo sapiens 
2012-09-15 | E-GEOD-34145 | biostudies-arrayexpress
TranscriptomicsGenome-wide identification of expression quantitative trait loci (eQTLs) in human heart
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-05-21 | E-GEOD-55232 | biostudies-arrayexpress
TranscriptomicsGenome-wide identification of expression quantitative trait loci (eQTLs) in human heart: genotyping
In recent years genome-wide association studies (GWAS) have uncovered numerous chromosomal loci associated with various electrocardiographic traits and cardiac arrhythmia predisposition. A considerable fraction of these loci lie within inter-genic regions. Trait-associated SNPs located in putative r...
ORGANISM(S): Homo sapiens 
2014-05-21 | E-GEOD-55230 | biostudies-arrayexpress
TranscriptomicsHigh-fat diet induced gene expression changes in mouse retina may be prevented by introducing bilberries in diet
Obesity and diabetes associated visual impairment and vascular dysfunctions are increasing reasons for vision loss. The detailed mechanisms in these diseases are still largely unknown, but mice models have been useful to study these mechanisms and explore the detailed effects of potential compounds....
ORGANISM(S): Mus musculus 
2012-09-08 | E-GEOD-34154 | biostudies-arrayexpress
GenomicsH3K27me3 ChIP-seq profiling in MCF7 cell lines under hypoxia
Purpose: Study hypoxia induced changes in genome-wide H3K27me3 occupancy Methods: Using the MCF7 breast epithelial adenocarcinoma cell line as a model, we studied epigenomic reprogramming as a function of fluctuating oxygen tension. To this end, we combined chromatin-immunoprecipitation and deep-seq...
ORGANISM(S): Homo sapiens 
2014-09-26 | E-GEOD-61740 | biostudies-arrayexpress
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