Sort   by:  
 Page size 
MetabolomicsInhibition of stress resilience and adult hippocampal neurogenesis by platelet-derived LPA16:0 in anxiety

Anxiety is an aggravating comorbidity of many psychiatric disorders that is often underdiagnosed and undertreated, and little is known on the mechanisms underlying its regulation. Here, we find that serum LPA16:0 abundance increases with trait anxiety in both humans and mice; while high LPA16:0 l...

2026-02-05 | MTBLS13589 | MetaboLights
ProteomicsMiR-135a-5p is critical for exercise-induced proliferation of adult neurogenesis
Physical exercise stimulates adult hippocampal neurogenesis in mammals, and is considered a relevant strategy for preventing age-related cognitive decline in aging humans. However, its mechanism is controversial. Here, by investigating microRNAs (miRNAs) and their downstream pathways, we uncover tha...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-12 | PXD009845 | Pride
Swath Mirna Adult neurogenesis 
TranscriptomicsSingle-cell RNA-seq with Waterfall Reveals Molecular Cascades underlying Adult Hippocampal Neurogenesis
Somatic stem cells contribute to tissue ontogenesis, homeostasis, and regeneration through sequential processes. Systematic molecular analysis of stem cell behavior is challenging because classic approaches cannot resolve cellular heterogeneity or capture developmental dynamics. Here we provide a co...
ORGANISM(S): Mus musculus 
2015-08-30 | E-GEOD-71485 | biostudies-arrayexpress
ProteomicsComprehensive proteome of the adult neural stem cell niche identifies key regulators of adult neurogenesis
Neural stem cells (NSCs) generating new neurons are restricted to few niches in the adult mammalian brain, while the remainder rather promotes gliogenesis. Here we take advantage of the spatial separation of an NSC niche (the subependymal zone) and the region to where the newly generated neurons mig...
ORGANISM(S): Mus musculus (Mouse) 
2020-01-27 | PXD016632 | Pride
Brain Stem cells Extracellular matrix Neurogenesis 
GenomicsFOXO3 shares common targets with ASCL1 genome-wide and inhibits ASCL1-dependent neurogenesis
FOXO transcription factors are central regulators of longevity from worms to humans. FOXO3 – the FOXO isoform associated with exceptional human longevity – preserves adult neural stem cell pools. Here we identify FOXO3 direct targets genome-wide in primary cultures of adult neural progenitor cells (...
ORGANISM(S): Mus musculus 
2013-08-13 | E-GEOD-48336 | biostudies-arrayexpress
UnknownMice in an enriched environment learn more flexibly because of adult hippocampal neurogenesis.
Not available
S-EPMC5049654 | biostudies-literature
TranscriptomicsExpression data from Ts1Cje and disomic C57BL/6 adult neurospheres
Down syndrome is the most common form of genetic mental retardation. How Trisomy 21 causes mental retardation remains unclear and its effects on adult neurogenesis have not been addressed. To gain insight into the mechanisms causing mental retardation we used microarrays to investigate gene expressi...
ORGANISM(S): Mus musculus 
2010-07-16 | E-GEOD-17760 | biostudies-arrayexpress
GenomicsMediator Med23 regulates adult hippocampal neurogenesis
Mediator Med23 regulates adult hippocampal neurogenesis
PRJNA638362 | ENA
TranscriptomicsIntegration of genome-wide approaches identifies lncRNAs of adult neural stem cells and their progeny in vivo [RNA-seq]
Long noncoding RNAs (lncRNAs) have been described in cell lines and various whole tissues, but lncRNA analysis of development in vivo is limited. Here, we comprehensively analyze lncRNA expression for the adult mouse subventricular zone neural stem cell lineage. We utilize complementary genome-wide ...
ORGANISM(S): Mus musculus 
2013-04-11 | E-GEOD-45278 | biostudies-arrayexpress
GenomicsAdult hippocampal neurogenesis in aged macaques and humans
Adult hippocampal neurogenesis in aged macaques and humans
PRJNA687392 | ENA
Sort   by:  
 Page size