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ProteomicsInteractome of Nematostella GW182 in HEK293 cells
Here, we dissect the function of GW182 protein in the cnidarian Nematostella, separated by 600 million years from other Metazoa. Using cultured human cells, we show that Nematostella GW182 recruits the CCR4-NOT deadenylation complexes via its tryptophan-containing motifs, thereby inhibiting translat...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080764 | MassIVE
TranscriptomicsmiRNA Profile in Three Different Normal Human Ocular Tissues by miRNA-Seq
Since microRNAs (miRNAs) have been associated with eye diseases, our study aims to profile ocular miRNA expression in normal human eye tissue using miRNA-Seq in order to provide a foundation for future disease research. Total RNAs were extracted from normal human ciliary body (CB) (n=7), cornea (n=7...
ORGANISM(S): Homo sapiens 
2016-08-01 | E-GEOD-81254 | biostudies-arrayexpress
TranscriptomicsPerformance Evaluation of Commercial miRNA Expression Array Platforms
This data is part of a miRNA platform comparison study. We compared the performance characteristics of four commercial miRNA array technologies and found that all platforms performed well in separate measures of performance. The Ambion and Agilent platforms were more accurate, whereas the Illumina ...
ORGANISM(S): Homo sapiens 
2010-06-23 | E-GEOD-19248 | biostudies-arrayexpress
TranscriptomicsPost-transcriptional generation of miRNA variants by multiple nucleotidyl transferases contributes to miRNA transcriptome complexity (Validation 1)
Modification of microRNA sequences by the 3' addition of nucleotides to generate so-called M-bM-^@M-^\isomiRsM-bM-^@M-^] adds to the complexity of miRNA function, with recent reports showing that 3' modifications can influence miRNA stability and efficiency of target repression. Here we show that th...
ORGANISM(S): synthetic construct 
2011-06-15 | E-GEOD-26916 | biostudies-arrayexpress
TranscriptomicsIntegrated expression profiles of mRNA and miRNA in polarized primary murine microglia (miRNA)
The aim of this study was to determine the role that miRNAs have on influencing murine microgial phenotypes under M1(LPS) and M2a (IL-4) stimulating conditions. This Series includes expression data obtained from miRNA gene expression microarrays; mRNA expression profiles obtained from the same RNA s...
ORGANISM(S): Mus musculus 
2014-03-13 | E-GEOD-49330 | biostudies-arrayexpress
TranscriptomicsThe human miRNA repertoire of different blood compounds
Background: MiRNAs from body fluids gain more and more attraction as biomarker candidates. Besides serum, patterns from whole blood are increasingly considered as markers for human pathologies. Usually, the contribution of different cell types to the respective signature remains however unknown. In ...
ORGANISM(S): Homo sapiens 
2014-06-16 | E-GEOD-56590 | biostudies-arrayexpress
TranscriptomicsmiRNA profiling of 29 cases of diffuse large B cell lymphoma
29 cases of RCHOP treated DLBCL were profiled for miRNA expression. Different integrated annalysis were performed, including mirNA differential expression between cases classified according to the COO signature (see later) and correlation tests between gene and miRNA expression. Cases classified acc...
ORGANISM(S): Homo sapiens 
2011-08-01 | E-GEOD-21847 | biostudies-arrayexpress
TranscriptomicsmiRNA profiling of 36 cases of diffuse large B cell lymphoma
miRNA expression data from 36 cases of RCHOP treated DLBCL samples were correlated with clinical variables in order to find miRNA signatures related with outcome. Cases classified according to the cell of origin classsifer (Wright G, Tan B, Rosenwald A, Hurt EH, Wiestner A, Staudt LM. A gene express...
ORGANISM(S): Homo sapiens 
2011-08-01 | E-GEOD-21848 | biostudies-arrayexpress
ProteomicsPlasma extracellular vesicle miRNA profiling in cervical cancer patients and healthy controls
Cervical cancer (CC) is a malignancy characterized by persistent HPV infection and tumor microenvironment remodeling. To explore the molecular characteristics of plasma extracellular vesicles (EVs) in CC, we performed miRNA sequencing on plasma EVs from 3 CC patients and 3 healthy controls. Differen...
ORGANISM(S): Homo sapiens (Human) 
2026-01-23 | PXD071100 | Pride
Cervical cancer Blood 
TranscriptomicsmiRNA Microarray Profiling: multiple tissues and cell lines
This SuperSeries is composed of the following subset Series: GSE11806: miRNA Microarray Profiling of Nine Different Normal Human Tissues GSE11840: miRNA Microarray Profiling with Three Different Total RNA Prep Methods Refer to individual Series
ORGANISM(S): Homo sapiens 
2008-08-19 | E-GEOD-11879 | biostudies-arrayexpress
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