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MetabolomicsAerobic exercise and gut flora: a key link to improved cognitive impairment in mice with Parkinson's disease

Parkinson's disease (PD) is a common neurodegenerative disorder. It is marked by motor dysfunction and cognitive decline. In recent years, scientific studies have found that PD's pathogenesis may be tied to an imbalance in the gut microbiota. This offers new perspectives for PD treatment. Modulat...

2025-10-12 | MTBLS13123 | MetaboLights
MetabolomicsPKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis
Metabolic reprogramming is a hallmark of cancer. Herein we discover that the key glycolytic enzyme pyruvate kinase M2 isoform (PKM2), but not the related isoform PKM1, is methylated by co-activator-associated arginine methyltransferase 1 (CARM1). PKM2 methylation reversibly shifts the balance of met...
2021-07-30 | MTBLS533 | MetaboLights
MetabolomicsSMAD3 and HIF-1α Orchestrate Metabolic Transition to Aerobic Glycolysis as a Critical Prerequisite for Spontaneous Reprogramming of Spermatogonial Stem Cells

Spermatogonial stem cells (SSCs) possess the capacity for spontaneous reprogramming during in vitro culture, while the underlying mechanisms remain poorly understood, especially why addition of epidermal growth factor (EGF), leukemia inhibitory factor (LIF) remarkably enhanced transition efficien...

2025-07-08 | MTBLS12698 | MetaboLights
Metabolomics4-octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects
Activated macrophages switch from oxidative phosphorylation to aerobic glycolysis, similar to the Warburg effect, presenting a potential therapeutic target in inflammatory disease. The endogenous metabolite itaconate has recently been reported to regulate macrophage function, but its precise mechani...
2019-10-02 | MTBLS1140 | MetaboLights
MetabolomicsThe Effects of Combined Aerobic and Resistance Exercise on Liver Metabolomics in Mice Fed a High-Fat Diet

Background and Objectives: Obesity is often accompanied by hepatic metabolic disorders and chronic low-grade inflammation. While combined aerobic and resistance exercise is considered an intervention to improve body composition, its systematic regulatory effects on the hepatic metabolic profile r...

2026-07-11 | MTBLS15011 | MetaboLights
MetabolomicsMetabolic programming and functional remodeling by a c-di-GMP-centric hierarchy in aerobic granular sludge

This study systematically elucidates the hierarchical signaling regulatory network in aerobic granular sludge (AGS) by integrating dynamic analysis of quorum sensing signal molecules, microbial community structure profiling, and metabolomic characterization. The research reveals that c-di-GMP fun...

2025-12-10 | MTBLS13486 | MetaboLights
ProteomicsAdaptation of Lacticaseibacillus rhamnosus CM MSU 529 to aerobic and respiratory growth: a proteomic approach
Lacticaseibacillus rhamnosus CM MSU 529 is the O2-tolerant facultative homofermentative lactic acid bacteria realizing respiratory metabolism when grown in a supplemented with hemin and vitamin K2 nutrient medium. This study describes the effect of aerobic and respiratory conditions on biomass and p...
ORGANISM(S): Lacticaseibacillus rhamnosus LRHMDP2 
2023-03-11 | PXD038847 | Pride
Lacticaseibacillus rhamnosus  aerobic conditions  respiratory conditions  oxidative stress  pyruvate oxidase  pyridoxine 5'-phosphate oxidase  nadh peroxidase  acetolactate synthase 
TranscriptomicsA transcriptional map of the impact of endurance exercise training on skeletal muscle phenotype (resting muscle after endurance training)
The molecular pathways which are activated and contribute to physiological remodeling of skeletal muscle in response to endurance exercise have not been fully characterized. We previously reported that ~800 gene transcripts are regulated following 6 weeks of supervised endurance training in young se...
ORGANISM(S): Homo sapiens 
2012-02-10 | E-GEOD-35659 | biostudies-arrayexpress
TranscriptomicsTranscriptome dynamics during the transition from anaerobic photosynthesis to aerobic respiration in R. sphaeroides
we performed time series microarray analyses to investigate transcriptome dynamics during the transition from anaerobic photosynthesis to aerobic respiration. Published on J. Bacteriol., 190 (1), 286-299, 2008. Major changes in gene expression profiles occurred in the initial 15 min after the shift ...
ORGANISM(S): Rhodobacter sphaeroides 2.4.1 
2008-07-28 | E-GEOD-12269 | biostudies-arrayexpress
ProteomicsFumarate effect on the Escherichia coli proteome at aerobic and anaerobic growth conditions
The changes in protein composition of E. coli were studied in a global proteomic approach for aerobic growth without or with fumarate as carbon source (glycerol + O2, fumarate + O2, respectively) and anaerobic growth without or with fumarate as carbon source (glycerol + DMSO, glycerol + DMSO + fumar...
ORGANISM(S): Escherichia coli 
2019-11-20 | PXD011760 | Pride
Escherichia coli  fumarate metabolism Aerobic/anaerobic growth  c4-dicarboxylates Lc-udmse 
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