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MetabolomicsPKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis
Metabolic reprogramming is a hallmark of cancer. Herein we discover that the key glycolytic enzyme pyruvate kinase M2 isoform (PKM2), but not the related isoform PKM1, is methylated by co-activator-associated arginine methyltransferase 1 (CARM1). PKM2 methylation reversibly shifts the balance of met...
2021-07-30 | MTBLS533 | MetaboLights
MetabolomicsSMAD3 and HIF-1α Orchestrate Metabolic Transition to Aerobic Glycolysis as a Critical Prerequisite for Spontaneous Reprogramming of Spermatogonial Stem Cells

Spermatogonial stem cells (SSCs) possess the capacity for spontaneous reprogramming during in vitro culture, while the underlying mechanisms remain poorly understood, especially why addition of epidermal growth factor (EGF), leukemia inhibitory factor (LIF) remarkably enhanced transition efficien...

2025-07-08 | MTBLS12698 | MetaboLights
Metabolomics4-octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects
Activated macrophages switch from oxidative phosphorylation to aerobic glycolysis, similar to the Warburg effect, presenting a potential therapeutic target in inflammatory disease. The endogenous metabolite itaconate has recently been reported to regulate macrophage function, but its precise mechani...
2019-10-02 | MTBLS1140 | MetaboLights
ProteomicsP2X7 signaling drives Th1 cell differentiation through metabolic reprogramming for aerobic glycolysis
This study provides evidence on the molecular mechanisms by which P2RX7 signaling promotes Th1 cell differentiation. P2RX7 induces T-bet expression and aerobic glycolysis in splenic CD4+ T cells that respond to malaria, at a time prior to Th1/Tfh polarization. Cell-intrinsic P2RX7 signaling sustains...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-08 | PXD037754 | Pride
Aerobic glycolysis Malaria P2x7 signaling Th1 cell differentiation 
ProteomicsGlobal Lactylation Profiling Reveals Lactate-Driven Regulatory Mechanisms Promoting Tumor Progression in Oral Carcinoma
Cancer cells often rely on aerobic glycolysis for metabolism, and lactylation, a newly discovered post-translational modification, significantly impacts molecular processes. This study comprehensively analyzes lactylation's role in oral squamous cell carcinoma (OSCC), providing initial insights into...
ORGANISM(S): Homo sapiens (Human) 
2024-08-23 | PXD047673 | Pride
Human Proteome Oral cancer 
ModelsShestov2014 - aerobic glycolysis
No description
2015-04-15 | MODEL1504010000 | BioModels
TranscriptomicsTranscription profiling of S. cerevisiae after prolonged selection in aerobic, glucose-limited chemostat cultures
Prolonged cultivation of Saccharomyces cerevisiae in aerobic, glucose-limited chemostat cultures (dilution rate, 0·10 h–1) resulted in a progressive decrease of the residual glucose concentration (from 20 to 8 mg l–1 after 200 generations). This increase in the affinity for glucose was accompan...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-16 | E-GEOD-8898 | biostudies-arrayexpress
TranscriptomicsLocust flight muscle: Tibetan Plateau population vs. North China Plain population
Background: Responses to hypoxia have been investigated in many species; however, comparative study between conspecific geographical populations in different altitude regions is rare, especially for invertebrates . The migratory locust, Locusta migratoria, is widely distributed both on high-altitude...
ORGANISM(S): Locusta migratoria 
2013-12-24 | E-GEOD-43327 | biostudies-arrayexpress
ProteomicsUFL1-Mediated UFMylation of ENO1 Restrains Aerobic Glycolysis and Colorectal Cancer Progression
Metabolic reprogramming toward enhanced aerobic glycolysis is a defining feature of cancer, yet how the contribution of ubiquitin-like modifications to this process remains poorly understood. Here, we identify the UFMylation E3 ligase UFL1 as a critical suppressor of glycolytic metabolism and colore...
ORGANISM(S): Homo sapiens (Human) 
2026-08-02 | PXD078510 | Pride
Ufmylation  ufl1  eno1  colorectal cancer  aerobic glycolysis 
TranscriptomicsExpression data of Actinobacillus pleuropneumoniae 4074 under aerobic and anaerobic environment
Actinobacillus pleuropneumoniae is an important porcine respiratory pathogen causing great economic losses in the pig industry worldwide. Oxygen deprivation is a stress that A. pleuropneumoniae will encounter during both early infection and the later, persistent stage. To understand modulation of A....
ORGANISM(S): Actinobacillus pleuropneumoniae serovar 1 str. 4074 
2014-06-30 | E-GEOD-39801 | biostudies-arrayexpress
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