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MetabolomicsB-cell Translocation Gene 2 Inhibits UFMylation Modification of FMO1 thus Restricting Taurine Synthesis and Exacerbating Ferroptosis in Hepatic Ischemia-Reperfusion Injury

Hepatic ischemia-reperfusion (I/R) injury is a common complication occurs during liver transplantation. However, the mechanisms underlying hepatic I/R injury have not been fully elucidated. B-cell translocation gene 2 (Btg2) has been implicated in the development of various diseases. However, its...

2026-03-07 | MTBLS11677 | MetaboLights
ProteomicsLC-MS/MS analysis of ribosome UFMylation in vitro
UFMylation, is a Ubiquitin-like modification occurring on RPL26, a ribosomal subunit, upon ribosome stalling at the ER membrane. This modification is achieved by a pool of enzymes commonly referred to as E1-activating, E2-conjugating and E3-ligase enzymes. The UFM1 E3 ligase comprises of three prote...
ORGANISM(S): Homo sapiens (Human) 
2024-03-22 | PXD046991 | Pride
In vitro reconstitution Rpl26 ufmylation Ribosome ufmylation 
ProteomicsOptimization of Protein UFMylation Modification Method and Its Application in Substrate Identification in Human Cells
In this study, we generated the UFSP1KO/UFSP2KO HEK293T cell line and validated it as the most suitable cellular model for the screening, identification, and confirmation of UFMylated substrate proteins. Furthermore, exogenous expression of the E3 ligase components UFL1 and DDRGK1 significantly enha...
ORGANISM(S): Homo sapiens (Human) 
2026-03-30 | PXD070408 | Pride
Ufsp Ufmylation Ufl1 Ddrgk1 Substrate 
ProteomicsProtein UFMylation regulates ribosomal DNA double-stranded break repair
Ribosomal DNA (rDNA) arrays are highly repetitive regions of the genome which encode essential genes required to produce ribosomes. DNA double-stranded breaks (DSBs) generated within rDNA genes elicit a unique cellular response involving robust transcriptional silencing and nucleolar reorganization ...
ORGANISM(S): Homo sapiens (Human) 
2024-09-16 | PXD048568 | Pride
Tcof1 Ufmylation Htert-rpe1 Treacle Nucleolus Ribosomal dna repair Lc-msms 
GenomicsUFMylation maintains YAP stability to promote vascular endothelial cell senescence
UFMylation maintains YAP stability to promote vascular endothelial cell senescence
PRJNA1143423 | ENA
ProteomicsShuffled ATG8 interacting motifs form an ancestral bridge between UFMylation and C53-mediated autophagy
UFMylation mediates the covalent modification of substrate proteins with UFM1 (Ubiquitin- fold modifier 1) and regulates the selective degradation of endoplasmic reticulum (ER) via autophagy (ER-phagy) to maintain ER homeostasis. Specifically, collisions of the ER-bound ribosomes trigger ribosome UF...
ORGANISM(S): Chlamydomonas reinhardtii 
2022-11-22 | PXD038157 | Pride
Chlamydomonas reinhardtii Rpl26 Er-phagy Ufmylation 
GenomicsRibosomal protein RPL26 is the principal target of UFMylation
Ribosomal protein RPL26 is the principal target of UFMylation
PRJNA509149 | ENA
GenomicsUFMylation anchors splicing factors at the ER to reprogram nuclear splicing
UFMylation anchors splicing factors at the ER to reprogram nuclear splicing
PRJNA1442193 | ENA
GenomicsAging-Associated Modulation of UFMylation Hampers Proteostasis in C. elegans
Aging-Associated Modulation of UFMylation Hampers Proteostasis in C. elegans
PRJNA1222315 | ENA
ProteomicsSite-specific identification of UFMylation by remnant VG-immunoprecipitation
Site specific proteomic identification of UFMylation sites: i) Comparision of antibody clones, ii) comparision of mouse tissues, iii) quantification in human skeletal muscle biopsies from ALS participants and controls
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2025-03-28 | PXD051412 | Pride
Ufm1 Ufmylation 
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