Sort   by:  
 Page size 
GenomicsTreacle-dependent TOPBP1 condensation regulates the nucleolar DNA damage response.
Treacle-dependent TOPBP1 condensation regulates the nucleolar DNA damage response.
PRJNA1403436 | ENA
ProteomicsTreacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation
Induction of DNA double-strand breaks (DSBs) in ribosomal DNA (rDNA) repeats is associated with ATM-dependent repression of ribosomal RNA synthesis and large-scale reorganization of nucleolar architecture, but the signaling events that regulate these responses are largely elusive. Here we show that ...
ORGANISM(S): Homo sapiens (Human) 
2019-12-06 | PXD015138 | Pride
Dna double.strand breaks Q exactive hf Treacle 
GenomicsTreacle-dependent TOPBP1 condensation regulates the nucleolar DNA damage response.
We show that Treacle promotes phase separation of TOPBP1 within the FC to initiate spatially confined n-DDR signaling and to direct rDNA repair pathway choice. Using both a reductionist FKBP-based system for inducible TOPBP1 oligomerization and physiological models of genotoxic rDNA damage, we demon...
ORGANISM(S): Homo sapiens 
2026-05-27 | GSE316591 | GEO
UnknownTreacle and TOPBP1 control replication stress response in the nucleolus.
Not available
S-EPMC8190600 | biostudies-literature
UnknownNucleolar Protein Treacle Is Important for the Efficient Growth of Mumps Virus.
Not available
S-EPMC9555161 | biostudies-literature
UnknownHenipaviruses and lyssaviruses target nucleolar treacle protein and regulate ribosomal RNA synthesis.
Not available
S-EPMC10947316 | biostudies-literature
UnknownThe NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage.
Not available
S-EPMC4962910 | biostudies-literature
UnknownTcof1/Treacle is required for neural crest cell formation and proliferation deficiencies that cause craniofacial abnormalities.
Not available
S-EPMC1557391 | biostudies-literature
UnknownTreacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation.
Not available
S-EPMC6949271 | biostudies-literature
UnknownMammalian neurogenesis requires Treacle-Plk1 for precise control of spindle orientation, mitotic progression, and maintenance of neural progenitor cells.
Not available
S-EPMC3315461 | biostudies-literature
Sort   by:  
 Page size