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MetabolomicsFecal Microbiota Transplantation Restores Gut Homeostasis and Enhances ER-Phagy to Mitigate Radiation-Induced Lung Injury

Radiation-induced lung injury (RILI) is a severe side effect of radiation therapy, characterized by lung tissue damage, inflammation, and organ dysfunction. Although fecal microbiota transplantation (FMT) has shown potential in alleviating radiation-induced damage, its underlying mechanisms ...

2026-01-05 | MTBLS12699 | MetaboLights
ProteomicsFAM134B oligomerization drives ER membrane scission for ER-phagy
ER degradation by selective autophagy (ER-phagy) is crucial for ER homeostasis. However, it remains unclear how ER scission is regulated for subsequent autophagosomal sequestration and lysosomal degradation. Here, we show that oligomer formation of FAM134B (also referred to as reticulophagy regulato...
ORGANISM(S): Homo sapiens (Human) 
2020-01-09 | PXD016661 | Pride
Er-phagy  fam134b oligomerization  membrane fragmentation  er stress  camk2b 
ProteomicsER-phagy restrains inflammatory responses through receptor UBAC2
ER-phagy, a selective degradation of endoplasmic reticulum (ER) fragment, plays a critical role in maintaining the ER homeostasis. Dysregulation of ER-phagy is involved in the unfolded protein response (UPR), which serves as a vital clue to evoke inflammatory disease. However, the molecular mechanis...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD052877 | Pride
Er-phagy  ubac2  mark2  inflammatory responses  colitis 
ProteomicsER-phagy restrains inflammatory responses through receptor UBAC2
ER-phagy, a selective degradation of endoplasmic reticulum (ER) fragment, plays a critical role in maintaining the ER homeostasis. Dysregulation of ER-phagy is involved in the unfolded protein response (UPR), which serves as a vital clue to evoke inflammatory disease. However, the molecular mechanis...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD052418 | Pride
Er-phagy  ubac2  mark2  inflammatory responses  colitis 
ProteomicsAn mTORC1-CK2 axis controls starvation induced ER-phagy via FAM134C
The degradation of endoplasmic reticulum (ER) via selective autophagy is driven by the ER-phagy receptors that facilitate the incorporation of ER-fragments into nascent autophagosomes. How these receptors are regulated, in response to ER-phagy-inducing stimuluses, is largely unknown. Here we propose...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2022-10-14 | PXD030451 | Pride
Human Fam134c Autophagy Rat Ck2 Mtorc1 Er-phagy 
ProteomicsTranscriptional regulation of ER-phagy by MiT/TFE factors controls chondrocyte differentiation and bone formation
Lysosomal-autophagic degradation of Endoplasmic Reticulum via autophagy (ER-phagy) is emerging as critical regulator of ER homeostasis and function. However, the molecular mechanisms governing ER-phagy are still unknown. Working in chondrocytes, we found that ER-phagy and lysosome biogenesis are co-...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-07-15 | PXD015331 | Pride
Phosphoprotemics Fgf signaling Er-phagy 
ProteomicsProteomic Landscape of Endoplasmic Reticulum Remodeling During Neurogenesis via Combinatorial Selective ER-phagy
The endoplasmic reticulum (ER) functions in protein and lipid synthesis, calcium ion flux, and inter-organelle communication, all of which are driven by the ER proteome landscape. ER is remodeled in part through autophagy-dependent protein turnover involving membrane-embedded ER-phagy receptors1,2. ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-08 | PXD041069 | Pride
Selective autophagy Er-phagy Human induced neurons Tmt 18-plex 
ProteomicsProteomic Landscape of Endoplasmic Reticulum Remodeling During Neurogenesis via Combinatorial Selective ER-phagy
The endoplasmic reticulum (ER) functions in protein and lipid synthesis, calcium ion flux, and inter-organelle communication, all of which are driven by the ER proteome landscape. ER is remodeled in part through autophagy-dependent protein turnover involving membrane-embedded ER-phagy receptors1,2. ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-08 | PXD046646 | Pride
Selective autophagy Er-phagy Human induced neurons Tmt 18-plex 
ProteomicsTranscriptional regulation of FAM134B by TFEB/TFE3 controls ER-phagy in response to starvation and chondrocyte differentiation
Lysosomal degradation of the endoplasmic reticulum (ER) via autophagy (ER-phagy) is emerging as a critical regulator of cell homeostasis and function1. The recent identification of ER-phagy receptors has shed light on the molecular mechanism underlining this process; however, the signaling pathways ...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-07-15 | PXD015326 | Pride
Lysosome Tfeb Er-phagy Chondrocyte 
ProteomicsUBAC2 phosphorylation is essential for its role in ER-phagy
ER-phagy, a selective degradation of endoplasmic reticulum (ER) fragment, plays a critical role in maintaining the ER homeostasis. Dysregulation of ER-phagy is involved in the unfolded protein response (UPR), which serves as a vital clue to evoke inflammatory disease. However, the molecular mechanis...
ORGANISM(S): Homo sapiens (Human) 
2025-08-01 | PXD052689 | Pride
Ubac2 er-phagy 
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