Sort   by:  
 Page size 
ProteomicsAn mTORC1-CK2 axis controls starvation induced ER-phagy via FAM134C
The degradation of endoplasmic reticulum (ER) via selective autophagy is driven by the ER-phagy receptors that facilitate the incorporation of ER-fragments into nascent autophagosomes. How these receptors are regulated, in response to ER-phagy-inducing stimuluses, is largely unknown. Here we propose...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2022-10-14 | PXD030451 | Pride
Human Fam134c Autophagy Rat Ck2 Mtorc1 Er-phagy 
ProteomicsFam134c and Fam134b shape axonal endoplasmic reticulum architecture in vivo.
Endoplasmic reticulum (ER) remodeling is vital for cellular organization. ER-phagy, a selective autophagy targeting ER, plays an important role in maintaining ER morphology and function. The FAM134 protein family, including FAM134A, FAM134B, and FAM134C, mediates ER-phagy. While FAM134B mutations ar...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-24 | PXD050983 | Pride
Fam134a Fam134b Fam134c Endoplasmic reticulum Axon 
UnknownReticulophagy receptor FAM134C restrains BMP receptor signaling.
Not available
S-EPMC12669696 | biostudies-literature
UnknownPhosphorylation of FAM134C by CK2 controls starvation-induced ER-phagy.
Not available
S-EPMC9432840 | biostudies-literature
UnknownFam134c and Fam134b shape axonal endoplasmic reticulum architecture in vivo.
Not available
S-EPMC11316074 | biostudies-literature
UnknownRTN4B interacting protein FAM134C promotes ER membrane curvature and has a functional role in autophagy.
Not available
S-EPMC8351555 | biostudies-literature
ProteomicsThe function of ER-phagy receptors is regulated through phosphorylation-dependent ubiquitination pathways.
Selective autophagy of the endoplasmic reticulum (ER), known as ER-phagy, is an important regulator of ER remodeling and is critical to maintaining cellular homeostasis during environmental changes. We recently showed that members of the FAM134 family play a role during stress-induced ER-phagy. How...
ORGANISM(S): Homo sapiens (Human) 
2023-11-16 | PXD043003 | Pride
Ck2 Er homeostasis Lysosomal degradation Er remodeling Er fragmentation Chek1 Atr Selective autophagy Atm Ubiquitination. Stress response Fam134b Fam134c Endoplasmic reticulum Mtor 
UnknownReticulophagy receptor FAM134C restrains BMP receptor signaling
Not available
S-SCDT-10_1038-S44318-025-00581-3 | biostudies-other
ProteomicsFunction of ERphagy receptors is regulated via phosphorylation-dependent ubiquitination pathways
Selective autophagy of the ER (ERphagy) is an important regulator of ER remodeling and critical to maintain cellular homeostasis upon environmental changes. ERphagy receptors link the ER with autophagic membrane thus regulating ERphagy flux. We recently showed that members of the FAM134 family play ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-17 | PXD036103 | Pride
Ck2 Er homeostasis Lysosomal degradation Er remodeling Er fragmentation Chek1 Atr Selective autophagy Atm Stress response Ubiquitination Fam134b Fam134c Endoplasmic reticulum Mtor 
UnknownFam134c and Fam134b shape axonal endoplasmic reticulum architecture in vivo.
Not available
S-SCDT-10_1038-S44319-024-00213-7 | biostudies-other
Sort   by:  
 Page size