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UnknownRecovery of FAM134A-mediated ER-phagy through BRD4 inhibition alleviates ethanol-induced neurodegeneration.
Not available
S-EPMC12435209 | biostudies-literature
ProteomicsProteome of Fam134A/B/C knock-out MEFs
Selective degradation of endoplasmic reticulum (ER) via autophagy receptors is important to maintain cell homeostasis. In this study we identify FAM134A/RETREG2 and FAM134C/RETREG3 as bona fide ER-phagy receptors containing a classical and functional LIR motif. In contrast to the other family member...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-23 | PXD021690 | Pride
Fam134 Er-phagy Collagen Proteome 
UnknownVariants in autophagy genes MTMR12 and FAM134A are putative modifiers of the hepatic phenotype in α1-antitrypsin deficiency.
Not available
S-EPMC11407773 | biostudies-literature
ProteomicsFam134c and Fam134b shape axonal endoplasmic reticulum architecture in vivo.
Endoplasmic reticulum (ER) remodeling is vital for cellular organization. ER-phagy, a selective autophagy targeting ER, plays an important role in maintaining ER morphology and function. The FAM134 protein family, including FAM134A, FAM134B, and FAM134C, mediates ER-phagy. While FAM134B mutations ar...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-24 | PXD050983 | Pride
Fam134a Fam134b Fam134c Endoplasmic reticulum Axon 
ProteomicsCritical functions of FAM134 family members in endoplasmic reticulum remodeling, ER-phagy and collagen quality control
Degradation of the endoplasmic reticulum (ER) by selective autophagy (ER-phagy) is vital for cellular homeostasis. Here, we introduce FAM134A/RETREG2 and FAM134C/RETREG3 as new ER-phagy receptors. FAM134A and FAM134C exist in a relatively inactive state under basal conditions and require an activati...
ORGANISM(S): Homo sapiens (Human) 
2021-06-23 | PXD025626 | Pride
Collagen Fam134 Endoplasmic reticulum Er-phagy Retreg Autophagy U2os. 
UnknownRole of FAM134 paralogues in endoplasmic reticulum remodeling, ER-phagy, and Collagen quality control.
Not available
S-EPMC8447607 | biostudies-literature
UnknownFam134c and Fam134b shape axonal endoplasmic reticulum architecture in vivo.
Not available
S-EPMC11316074 | biostudies-literature
UnknownGenome-scale single-cell mechanical phenotyping reveals disease-related genes involved in mitotic rounding.
Not available
S-EPMC5668354 | biostudies-literature
UnknownThe crystal structure of the FAM134B-GABARAP complex provides mechanistic insights into the selective binding of FAM134 to the GABARAP subfamily.
Not available
S-EPMC8727931 | biostudies-literature
UnknownPhosphorylation of FAM134C by CK2 controls starvation-induced ER-phagy.
Not available
S-EPMC9432840 | biostudies-literature
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