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MetabolomicsMitochondrial NAD+ Deficiency in Vascular Smooth Muscle Impairs Collagen III Turnover to Trigger Aortic Disease

Aortic disease poses a significant mortality risk in adults, yet many of its underlying factors remain undiscovered. In this study, we identify mitochondrial NAD⁺ deficiency as a causal factor. Metabolomics analysis of 73 surgical aortic specimens revealed impaired NAD⁺ salvage and mitochondrial ...

2024-12-04 | MTBLS8062 | MetaboLights
MetabolomicsCollagen induced arthritis in dba/1j mice associates with oxylipin changes in plasma
Oxylipins play important roles in various biological processes and are considered as mediators of inflammation for a wide range of diseases such as rheumatoid arthritis (RA). The purpose of this research was to study differences in oxylipin levels between a widely used collagen-induced arthritis (CI...
2015-11-04 | MTBLS243 | MetaboLights
ProteomicsData for Mass spectrometry analysis of collagen IV
Data for PHFR9 7S: 1. Raw file (6 files) 2. IDPicker files (1 file) 3. Database (1 file) Data for EHS mouse collagen IV: 1.Raw file ( 21 files) 2.IDPicker files (7 files) 3.Database (3 files) Mouse_data_CID_1=Trypsin;Mouse_data_CID_2=Glu C; Mouse_data_CID_3=Trypsin +Glu C; Mouse_data_ETD_1=Trypsin (...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2015-08-17 | MSV000079260 | MassIVE
TranscriptomicsTranscription profiling of human fibroblasts grown on TCPS plates, Collagen-GAG 2 D plate and Collagen-GAG 3D mesh
All mRNA was isolated after 8 hours of culture time in each of three culture conditions. (1) TCPS Plate, (2) Collagen-GAG 2 dimensional coated plate and (3) collagen-GAG three dimensional mesh.
ORGANISM(S): Homo sapiens 
2008-06-11 | E-GEOD-1937 | biostudies-arrayexpress
TranscriptomicsCollagen Dynamics and Transcriptional Profiling in Bleomycin-induced Pulmonary Fibrosis
Collagen deposition is a key process during idiopathic pulmonary fibrosis (IPF); however, little is known about the dynamics of collagen formation during disease development. Tissue samples of early stages of human disease are not readily available and it is difficult to identify changes in collagen...
ORGANISM(S): Mus musculus 
2013-05-26 | E-GEOD-37635 | biostudies-arrayexpress
ProteomicsCyclophilin B deficiency causes abnormal dentin collagen matrix
To evaluate the effects of cyclophilin B deficiency on expression levels of collagen family members in dentin, we performed protein identification of cyclophilin B-WT, -Het, and -KO teeth after trypsin digestion.
ORGANISM(S): Mus Musculus (mouse) 
2017-07-20 | PXD006021 | JPOST Repository
TranscriptomicsCathepsin K Contributes to Cavitation and Collagen Turnover in Pulmonary Tuberculosis
Cavitation in tuberculosis (TB) enables highly efficient person-to-person aerosol transmission. Currently, a number of hypotheses exist regarding the mechanisms underlying this process. To explore this process, we undertook an unbiased next-generation transcriptional analysis of samples from cavity ...
ORGANISM(S): Oryctolagus cuniculus 
2015-11-03 | E-GEOD-68206 | biostudies-arrayexpress
TranscriptomicsRNA-seq of cancer cell collagen tracks
Collagen tracks deposited by breast cancer cells contain specific miRNAs which reprogram non-invasive cells into highly pro-metastatic ones by inducing a partial epithelial–mesenchymal transition (EMT) associated with an increase in ECM degradation and cell invasiveness.
ORGANISM(S): Homo sapiens 
2025-12-14 | E-MTAB-15636 | biostudies-arrayexpress
ProteomicsPreservation of collagen in the soft tissue of frozen mammoths
To evaluate whether collagen is preserved in the soft tissues of frozen mammoths for 40,000 years, we performed protein identification of mammoth lung and kidney (and elephant bone and kidney as controls) after trypsin digestion.
ORGANISM(S): Mammuthus Primigenius Elephas Maximus Indicus 
2021-10-05 | PXD024006 | JPOST Repository
ProteomicsLysyl hydroxylase 3 mediated post-translational modifications are required for proper biosynthesis of collagen a1a1a2(IV)
We performed proteomic identification of type IV collagen gel bands from wild-type and lysyl hydroxylase 3 knockout cells by LC-MS after trypsin digestion.
ORGANISM(S): Mus Musculus (mouse) 
2022-11-21 | PXD035051 | JPOST Repository
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