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GenomicsEucalyptus grandis cultivar:FAM134
Eucalyptus grandis FAM134 Resequencing
PRJNA1323274 | ENA
UnknownRole of FAM134 paralogues in endoplasmic reticulum remodeling, ER-phagy, and Collagen quality control.
Not available
S-EPMC8447607 | biostudies-literature
ProteomicsFunction of ERphagy receptors is regulated via phosphorylation-dependent ubiquitination pathways
Selective autophagy of the ER (ERphagy) is an important regulator of ER remodeling and critical to maintain cellular homeostasis upon environmental changes. ERphagy receptors link the ER with autophagic membrane thus regulating ERphagy flux. We recently showed that members of the FAM134 family play ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-17 | PXD036103 | Pride
Ck2 Er homeostasis Lysosomal degradation Er remodeling Er fragmentation Chek1 Atr Selective autophagy Atm Stress response Ubiquitination Fam134b Fam134c Endoplasmic reticulum Mtor 
ProteomicsProteome of Fam134A/B/C knock-out MEFs
Selective degradation of endoplasmic reticulum (ER) via autophagy receptors is important to maintain cell homeostasis. In this study we identify FAM134A/RETREG2 and FAM134C/RETREG3 as bona fide ER-phagy receptors containing a classical and functional LIR motif. In contrast to the other family member...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-23 | PXD021690 | Pride
Fam134 Er-phagy Collagen Proteome 
ProteomicsCritical functions of FAM134 family members in endoplasmic reticulum remodeling, ER-phagy and collagen quality control
Degradation of the endoplasmic reticulum (ER) by selective autophagy (ER-phagy) is vital for cellular homeostasis. Here, we introduce FAM134A/RETREG2 and FAM134C/RETREG3 as new ER-phagy receptors. FAM134A and FAM134C exist in a relatively inactive state under basal conditions and require an activati...
ORGANISM(S): Homo sapiens (Human) 
2021-06-23 | PXD025626 | Pride
Collagen Fam134 Endoplasmic reticulum Er-phagy Retreg Autophagy U2os. 
UnknownRole of FAM134 paralogues in endoplasmic reticulum remodeling, ER-phagy and Collagen quality control
Not available
S-SCDT-EMBOR-2020-52289-T | biostudies-other
UnknownThe function of ER-phagy receptors is regulated through phosphorylation-dependent ubiquitination pathways.
Not available
S-EPMC10724265 | biostudies-literature
UnknownFam134c and Fam134b shape axonal endoplasmic reticulum architecture in vivo.
Not available
S-EPMC11316074 | biostudies-literature
ProteomicsThe function of ER-phagy receptors is regulated through phosphorylation-dependent ubiquitination pathways.
Selective autophagy of the endoplasmic reticulum (ER), known as ER-phagy, is an important regulator of ER remodeling and is critical to maintaining cellular homeostasis during environmental changes. We recently showed that members of the FAM134 family play a role during stress-induced ER-phagy. How...
ORGANISM(S): Homo sapiens (Human) 
2023-11-16 | PXD043003 | Pride
Ck2 Er homeostasis Lysosomal degradation Er remodeling Er fragmentation Chek1 Atr Selective autophagy Atm Ubiquitination. Stress response Fam134b Fam134c Endoplasmic reticulum Mtor 
ProteomicsFam134c and Fam134b shape axonal endoplasmic reticulum architecture in vivo.
Endoplasmic reticulum (ER) remodeling is vital for cellular organization. ER-phagy, a selective autophagy targeting ER, plays an important role in maintaining ER morphology and function. The FAM134 protein family, including FAM134A, FAM134B, and FAM134C, mediates ER-phagy. While FAM134B mutations ar...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-24 | PXD050983 | Pride
Fam134a Fam134b Fam134c Endoplasmic reticulum Axon 
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