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ProteomicsATR inhibition rewires cellular signaling networks in response to pathologic replication stress
DNA replication stress is the major cause of genomic instability in human cells. The ataxia telangiectasia and Rad3-related kinase (ATR) plays an essential role in the cellular response to replication stress and inhibition of ATR has emerged as therapeutic strategy for the treatment of cancer. Howev...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080795 | MassIVE
ProteomicsTherapeutic targeting of ATR in alveolar rhabdomyosarcoma
Despite advances in multi-modal treatment approaches, clinical outcomes of patients suffering from PAX3-FOXO1 fusion oncogene-expressing alveolar rhabdomyosarcoma (ARMS) remain dismal. Here we show that PAX3-FOXO1-expressing ARMS cells are sensitive to pharmacological ataxia telangiectasia and Rad3 ...
ORGANISM(S): Homo Sapiens (human) 
2022-07-11 | PXD035131 | JPOST Repository
ProteomicsTotal and phosphoproteome analysis of effects of topoisomerase 1 and ATR inhibitors in small cell lung cancer nuclei
Total and phosphoproteome analysis of effects of topoisomerase 1 (SN-38) and ATR (M1774) inhibitors in small cell lung cancer. Experiments performed in nuclear extract. See MetaData for more information.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-02-21 | MSV000091336 | MassIVE
TranscriptomicsTranscription profiling of shoot apices from Arabidopsis wild type, teb, atr, and teb atr mutant plants
Global gene expression patterns were compared among wild-type Col-0, teb, atr, teb atr of A. thaliana using shoot apices.
ORGANISM(S): Arabidopsis thaliana 
2008-04-01 | E-MEXP-1329 | biostudies-arrayexpress
ProteomicsHuman serine/threonine protein kinase ATR LC-MS/MS
ATR is a PI3K-like kinase protein, regulating checkpoint responses to DNA damage and replication stress. Apart from its checkpoint function in the nucleus, ATR actively engage in antiapoptotic role at mitochondria following DNA damage. The different functions of ATR in the nucleus and cytoplasm are ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD031385 | Pride
Biotin modification Cis/trans prolyl isomerization Mass protein footprinting Bh3-like domain Atr 
ProteomicsMapping of ATR–ATRIP phosphorylation sites before and after autophosphorylation
ATR–ATRIP is activated upon binding to TopBP1, and this activation is driven by TopBP1-mediated autophosphorylation. To identify the phosphorylation sites associated with ATR–ATRIP activation, we prepared ATR–ATRIP samples before and after autophosphorylation and performed nano-HPLC–MS/MS analysis t...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-18 | PXD082486 | Pride
Phosphorylation sites Activation Atr-atrip 
ProteomicsConvergence of SIRT1 and ATR signaling to modulate replication origin dormancy
SIRT1 chromatin interactome analysis was performed to identify SIRT1 molecular targets involved in replication initiation from cells containing either WT or H363Y SIRT1. Co-IP-MS of pT530 SIRT1 from chromatin extracts was performed. Files are: 1422 WT SIRT1 untreated U2OS; 1423 WT SIRT1 H2O2 treated...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000088103 | MassIVE
GenomicsSporomusa sp. ATR-1
Sporomusa sp. ATR-1 Genome sequencing and assembly
PRJNA1081654 | ENA
TranscriptomicsTranscriptional response to zebularine and mitomycin C (MMC) in wild type and ATR deficient Arabidopsis thaliana plants
Zebularine is a non-methylable cytidine analog that is used in epigenetic and cancer research. Its application has been shown to activate several transcriptionally silenced genetic elements; however, extent of this activation and other effects on the transcriptome are unknown. Here, we show that zeb...
ORGANISM(S): Arabidopsis thaliana 
2014-11-18 | E-GEOD-63355 | biostudies-arrayexpress
GenomicsHistophilus somni strain:UOC-KLM-ATR-04
Histophilus somni strain:UOC-KLM-ATR-04 Genome sequencing
PRJNA560594 | ENA
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