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TranscriptomicsMicroarray analysis of gene expression in ATM-deficient MEFs
The expression of interferon-related genes was more enhanced in irradiated ATM-deficient mouse embryonic fibroblasts (MEFs) than in irradiated ATM wild-type MEFs. Nonirradiated-ATM-WT vs Irradiated-ATM-WT vs Nonirradaited-ATM-KO vs IrradiatedATM-KO
ORGANISM(S): Mus musculus 
2012-06-19 | E-GEOD-23116 | biostudies-arrayexpress
TranscriptomicsATM-deficient B cell lymphomas
Ataxia-telangiectasia mutated (ATM) kinase plays a central role in maintaining genomic integrity. In both humans and mice, ATM deficiency is associated with an increased incidence of lymphoid cancers that are primarily T cell in origin. We demonstrate here that when T cells are removed as targets fo...
ORGANISM(S): Mus musculus 
2015-12-09 | E-GEOD-68505 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of ATM +/+, ATM +/- and ATM -/- human lymphoblastoid cell lines exposed to 5 Gy IR at 0, 4 and 24 hours to identify expression phenotypes in Ataxia Telangiectasia carriers and patients
Transcription profiling of ATM (Ataxia Telangiectasia Mutated) +/+ (Control), ATM +/- (AT Carrier) and ATM -/- (AT patient) human lymphoblastoid cell lines exposed to 5 Gy IR at 0, 4 and 24 hours to identify expression phenotypes in Ataxia Telangiectasia carriers and patients
ORGANISM(S): Homo sapiens 
2008-07-29 | E-TABM-321 | biostudies-arrayexpress
TranscriptomicsEffect of TERT and ATM on Gene Expression Profiles in Human Fibroblasts
Gene expression profiling was performed by use of serial analysis of gene expression (SAGE) on BJ normal human skin fibroblasts, A-T cells, and BJ and A-T cells transduced with hTERT cDNA and expressing telomerase activity. Keywords = telomere Keywords = telomerase Keywords = TERT Keywords = ataxia ...
ORGANISM(S): Homo sapiens 
2004-01-16 | E-GEOD-953 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of ATM deficient human mammary epithelial cells
Deficiencies in the ATM gene are the underlying cause for ataxia telangiectasia, a congenital syndrome characterized by neurological, motor and immunological defects, as well as a predisposition to cancer risks. MicroRNAs (miRNAs) are small regulators of post-transcriptional gene expression and a us...
ORGANISM(S): Homo sapiens 
2013-08-22 | E-GEOD-36082 | biostudies-arrayexpress
no omics definedTranscription profiling of wild type and Atm-/- mouse lymph nodes treated with ionizing radiation
The DNA damage response network modulates a wide array of signaling pathways, including DNA repair, cell cycle checkpoints, apoptotic pathways and numerous stress signals. The ATM protein kinase, functionally missing in patients with the human genetic disorder ataxia-telangiectasia (A-T), is a maste...
ORGANISM(S): Mus musculus 
2007-12-04 | E-GEOD-2118 | biostudies-arrayexpress
TranscriptomicsWIP1 controls global heterochromatin silencing via ATM/BRCA1-dependent DNA methylation
WIP1 phosphatase is emerging as an important regulator of tumorigenesis, but no unifying mechanistic network has been proposed. Here we found that WIP1 plays a key role in the transcriptional regulation of heterochromatin-associated DNA sequences in germ-line and cancer cells. WIP1 was required for ...
ORGANISM(S): Mus musculus 
2013-10-19 | E-GEOD-46103 | biostudies-arrayexpress
TranscriptomicsSmall RNA-seq and gene expression analysis reveal a miRNA profile of cancer-susceptibility in ATM deficient human mammary epithelial cells (Small RNA-Seq)
Deficiencies in the ATM gene are the underlying cause for ataxia telangiectasia, a congenital syndrome characterized by neurological, motor and immunological defects, as well as a predisposition to cancer risks. MicroRNAs (miRNAs) are small regulators of post-transcriptional gene expression and a us...
ORGANISM(S): Homo sapiens 
2013-08-22 | E-GEOD-36266 | biostudies-arrayexpress
TranscriptomicsATM Requirement in Gene Expression Responses to Ionizing Radiation in Human Lymphoblasts and Fibroblasts
Investigation of ATM-dependent and dose-dependent, or -independent, responses were examined in human lymphoblast cells 6 hr following exposure to either 1 or 5 Gy ionizing radiation. Human lymphoblast cells from "apparently healthy" individuals and individuals with Ataxia telangiectasia were exposed...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-3174 | biostudies-arrayexpress
TranscriptomicsInfluence of ATM-mediated DNA damage response on genomic variation in human induced pluripotent stem cells (NimbleGen CNV)
Genome instability is a potential limitation to the research and therapeutic application of induced pluripotent stem cells (iPSCs). Observed genomic variations reflect the combined activities of DNA damage, cellular DNA damage response (DDR), and selection pressure in culture. To understand the cont...
ORGANISM(S): Homo sapiens 
2016-03-29 | E-GEOD-78717 | biostudies-arrayexpress
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