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GenomicsTranscriptome analysis of CHEK1 overexpression (AC or HC) VS control (A or H) and CHEK1 knockdown (AK_D or HK_D) VS control (AK or HK) in Mutiple Myeloma.
Transcriptome analysis of CHEK1 overexpression (AC or HC) VS control (A or H) and CHEK1 knockdown (AK_D or HK_D) VS control (AK or HK) in Mutiple Myeloma.
PRJNA645306 | ENA
ProteomicsLiP-MS on CHEK1 Purified from HEK293 cells treated with Rabusertib
Limited proteolysis coupled to mass spectrometry (LiP-MS) is a structural proteomics technique that can be used to identify the targets of small molecules. This is achieved by incubating lysate with the drug of interest, which induces structural changes such as occupation of the binding site or chan...
ORGANISM(S): Homo sapiens (Human) 
2025-04-30 | PXD058318 | Pride
Chemical probe Lip-ms 
GenomicsNobiletin targets CHEK1-H3K27ac-CENPM axis and suppresses the malignancy of colorectal cancer
Nobiletin targets CHEK1-H3K27ac-CENPM axis and suppresses the malignancy of colorectal cancer
PRJNA1269447 | ENA
TranscriptomicsTranscriptome analysis of CHEK1 overexpression (AC or HC) VS control (A or H) and CHEK1 knockdown (AK_D or HK_D) VS control (AK or HK) in Mutiple Myeloma.
Transcriptome sequencing was used to analyze changes in related signaling pathways and gene expression in Mutiple Myeloma cells when CHEK1 was overexptressed or knocked down.
ORGANISM(S): Homo sapiens 
2020-07-11 | GSE154164 | GEO
GenomicsIntegrative miRNOMe profiling reveals the miR-195-5p-CHEK1 axis and its impact on luminal breast cancer outcomes
Integrative miRNOMe profiling reveals the miR-195-5p-CHEK1 axis and its impact on luminal breast cancer outcomes
PRJNA1111806 | ENA
UnknownCHEK1 and circCHEK1_246aa evoke chromosomal instability and induce bone lesion formation in multiple myeloma.
Not available
S-EPMC8178856 | biostudies-literature
GenomicsIntegrative miRNOMe profiling reveals the miR-195-5p-CHEK1 axis and its impact on luminal breast cancer outcomes
The luminal subtype (estrogen receptor-positive, ER+) is the most common and the most heterogeneous type of breast carcinoma (BC) in women. During our study, we determined expression levels of all microRNAs (miRNOMe) in 101 ER+ BC samples and identified 25 miRNAs being associated with proliferative ...
ORGANISM(S): Homo sapiens 
2025-05-15 | GSE267543 | GEO
UnknownAssociations of ATR and CHEK1 single nucleotide polymorphisms with breast cancer.
Not available
S-EPMC3700940 | biostudies-literature
UnknownCHEK1 coordinates DNA damage signaling and meiotic progression in the male germline of mice.
Not available
S-EPMC6185175 | biostudies-literature
UnknownThe Atr-Chek1 pathway inhibits axon regeneration in response to Piezo-dependent mechanosensation.
Not available
S-EPMC8219705 | biostudies-literature
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