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ProteomicsStructural impact of TM domain mutations on mycobacterial adenylyl cyclase Rv1625c (LiP-MS)
LiP-MS was used to assess the structural impact of transmembrane domain mutations on the overall conformation of the mycobacterial cycase Rv1625c.
ORGANISM(S): Mycobacterium tuberculosis SUMu001 Escherichia coli 
2022-08-19 | PXD033826 | Pride
Protein structure Lip-ms Membrane protein Lc-ms/ms 
ProteomicsLimited-proteolysis coupled to mass spectrometry (LiP-MS) data on a serially filtered yeast lysate (the FLiP library) and on lysates of wild-type and Gcn5 mutant yeast strains grown under hydroxyurea stress and control conditions. Affinity purification mass spectrometry on Ada3 pulldowns from yeast grown under hydroxyurea stress and control conditions.
We applied serial ultrafiltration and limited proteolysis-coupled mass spectrometry (LiP-MS) to generate an atlas of peptides that act as markers for the formation or dissolution of protein-protein interactions (PPIs). Applied to Saccharomyces cerevisiae, the approach yielded 6,441 candidate PPI mar...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-10-17 | PXD055566 | Pride
Ap-ms Flip-ms Hydroxyurea Ada3 Lip-ms 
ProteomicsLiP-MS on Purified CAMKK1 treated with Staurosporine
Limited proteolysis coupled to mass spectrometry (LiP-MS) is a structural proteomics technique that can be used to identify the targets of small molecules. This is achieved by incubating protein with the drug of interest, which induces structural changes such as occupation of the binding site or cha...
ORGANISM(S): Homo sapiens (Human) 
2023-04-26 | PXD041089 | Pride
Target engagement Lip-ms 
ProteomicsAnalysis of human AKT PH domain using limited proteolysis (LiP) followed by LC-MS/MS
We identified that a lncRNA named Long Intergenic Noncoding RNA for Kinase Activation (LINK-A, also LINC01139) directly and specifically interacts with AKT and PIP3. The LINK-A-AKT and -PIP3 interactions facilitate AKT recruitment and consequent activation. we also identified the single nucleotides ...
ORGANISM(S): Homo sapiens (Human) 
2017-02-10 | PXD005636 | Pride
Human Pip3 Akt Ph domain Lip Lc-ms/ms 
ProteomicsLiP-MS
LiP-MS
2025-07-11 | OEX00032359 | NODE
ProteomicsRapid and Label-Free Structural Proteomics by One-Step Swift Trypsin LiP-MS
We developed a rapid, surface-targeted limited proteolysis workflow, Swift Trypsin LiP-MS (STLiP-MS), to profile proteome-wide structural changes under near-native conditions. STLiP-MS uses a trypsin-immobilized spin column and centrifugation-controlled contact to achieve instantaneous, highly repro...
ORGANISM(S): Homo Sapiens (human) Cellular Organisms 
2026-01-05 | PXD069771 | JPOST Repository
ProteomicsLiP-MS on CAMK1 Purified from HEK293 cells treated with CS640
Limited proteolysis coupled to mass spectrometry (LiP-MS) is a structural proteomics technique that can be used to identify the targets of small molecules. This is achieved by incubating lysate with the drug of interest, which induces structural changes such as occupation of the binding site or chan...
ORGANISM(S): Homo sapiens (Human) 
2025-04-30 | PXD058292 | Pride
Chemical probe Lip-ms 
ProteomicsLiP-MS on CHEK1 Purified from HEK293 cells treated with Rabusertib
Limited proteolysis coupled to mass spectrometry (LiP-MS) is a structural proteomics technique that can be used to identify the targets of small molecules. This is achieved by incubating lysate with the drug of interest, which induces structural changes such as occupation of the binding site or chan...
ORGANISM(S): Homo sapiens (Human) 
2025-04-30 | PXD058318 | Pride
Chemical probe Lip-ms 
ProteomicsLiP-MS on CASK Purified from HEK293 cells treated with NR162
Limited proteolysis coupled to mass spectrometry (LiP-MS) is a structural proteomics technique that can be used to identify the targets of small molecules. This is achieved by incubating lysate with the drug of interest, which induces structural changes such as occupation of the binding site or chan...
ORGANISM(S): Homo sapiens (Human) 
2025-04-30 | PXD058317 | Pride
Chemical probe Lip-ms 
ProteomicsLiP-MS on PRKCA Purified from HEK293 cells treated with Go 6983
Limited proteolysis coupled to mass spectrometry (LiP-MS) is a structural proteomics technique that can be used to identify the targets of small molecules. This is achieved by incubating lysate with the drug of interest, which induces structural changes such as occupation of the binding site or chan...
ORGANISM(S): Homo sapiens (Human) 
2025-04-30 | PXD058320 | Pride
Chemical probe Lip-ms 
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