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ProteomicsHuman Platelet PIP3 Signalosome
Platelets are small, anucleate cells that play an essential role in haemostasis, but can contribute critically to the pathogenesis of cardiovascular disease. Platelets express all four Class I Phosphoinositide 3-kinase (PI3K) isoforms, with previous work revealing important roles for these enzymes ...
ORGANISM(S): Homo sapiens (Human) 
2017-06-06 | PXD003777 | Pride
Lc-msms Platelet Pip3 Pi3k Platelets 
ProteomicsTrifunctional PIP3 binder identification
Trifunctional PIP3 is a chemically modified derivate of PIP3 that includes 3 functionalized groups allowing spacial an temporal manipulation of its release and function. A caged group allows for timed release of the coumpound, a cross-linking group induces covalent binding to binders, while a clicka...
ORGANISM(S): Homo sapiens (Human) 
2025-02-19 | PXD025903 | Pride
Hela Pip3 Trifunctional 
TranscriptomicsPerturbations of PIP3 signaling trigger a global remodeling of mRNA landscape and reveal a transcriptional feedback loop
PIP3 is synthesized by PI3Ks and regulates complex cell responses, such as growth and migration. Signals that drive long-term reshaping of cell phenotypes are difficult to resolve because of complex feedback networks that operate over extended times. It is clear PIP3-dependent modulation of mRNA acc...
ORGANISM(S): Homo sapiens 
2015-10-02 | GSE69822 | GEO
TranscriptomicsBiological function of Pip3
Ralstonia solanacearum is the causal agent of bacterial wilt. Arabidopsis thaliana monogenic resistance to the strain GMI1000 is conferred by the RRS1-R gene, present in the resistant ecotype ND-1 and absent in the susceptible ecotype Col-0. The corresponding protein is recognized by the avirulence ...
ORGANISM(S): Arabidopsis thaliana 
2009-12-09 | E-GEOD-19273 | biostudies-arrayexpress
ProteomicsAnalysis of human AKT PH domain using limited proteolysis (LiP) followed by LC-MS/MS
We identified that a lncRNA named Long Intergenic Noncoding RNA for Kinase Activation (LINK-A, also LINC01139) directly and specifically interacts with AKT and PIP3. The LINK-A-AKT and -PIP3 interactions facilitate AKT recruitment and consequent activation. we also identified the single nucleotides ...
ORGANISM(S): Homo sapiens (Human) 
2017-02-10 | PXD005636 | Pride
Human Pip3 Akt Ph domain Lip Lc-ms/ms 
UnknownIncreased PIP3 activity blocks nanoparticle mRNA delivery.
Not available
S-EPMC7375820 | biostudies-literature
TranscriptomicsBiological function of Pip3
Ralstonia solanacearum is the causal agent of bacterial wilt. Arabidopsis thaliana monogenic resistance to the strain GMI1000 is conferred by the RRS1-R gene, present in the resistant ecotype ND-1 and absent in the susceptible ecotype Col-0. The corresponding protein is recognized by the avirulence ...
ORGANISM(S): Arabidopsis thaliana 
2009-12-10 | GSE19273 | GEO
UnknownPIP3 waves and PTEN dynamics in the emergence of cell polarity.
Not available
S-EPMC3446687 | biostudies-literature
UnknownMutual inhibition between PTEN and PIP3 generates bistability for polarity in motile cells.
Not available
S-EPMC6203803 | biostudies-literature
UnknownTransport of PIP3 by GAKIN, a kinesin-3 family protein, regulates neuronal cell polarity.
Not available
S-EPMC2064238 | biostudies-literature
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