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TranscriptomicsmiRNA expression profiles of erythroid cells following hydroxyurea treatment for sickle cell anemia
We hypothesized that miRNA regulation may be invloved in hydroxyurea-mediated fetal hemoglobin induction. Microarray analysis was utilized as an initial screening tool to determine differential miRNA expression in CD71+ erythroid cells comparing cells from control individuals without sickle cell ane...
ORGANISM(S): Homo sapiens 
2011-11-21 | E-GEOD-32035 | biostudies-arrayexpress
TranscriptomicsOxidative Stress Mechanisms of Hydroxyurea-Induced Developmetal Toxicity in Organogenesis Stage Mouse Embryos
To investigate the gene expression changes in gestational day 9 embryos exposed to hydroxyurea in utero. Agilent microarray technology was used to identify genes that responded to hydroxyurea exposure. Understanding the stress response of the embryo will help us advance education of birth defect pre...
ORGANISM(S): Mus musculus 
2015-01-15 | E-GEOD-54579 | biostudies-arrayexpress
Transcriptomicsp53 and p73 ChIP-chip experiments in HCT116-3(6) cells
The p53-family of transcription factors share a highly homologous DNA binding domain and have overlapping and distinct biological functions. Using chromatin immunoprecipitation in combination with NimbleGen promoter arrays and a Model-based Algorithm for Promoter arrays (MAP), we performed a direct ...
ORGANISM(S): Homo sapiens 
2009-06-30 | E-GEOD-12224 | biostudies-arrayexpress
GenomicsGenome-wide binding of hSTN1 in response to hydroxyurea-induced replication stress
We find that hSTN1 is preferentially enriched at GC-rich repetitive sequences genome-wide after hydroxyurea treatment. HeLa cells stably expressing myc-tagged hSTN1 were treated with 2 mM hydroxyurea, crosslinked, and ChIP-seq was performed.
ORGANISM(S): Homo sapiens 
2016-08-06 | E-GEOD-82123 | biostudies-arrayexpress
TranscriptomicsExpression data for T47D cells treated with 2mM hydroxyurea
RAD51B, a paralog of RAD51, have been associated with breast cancer risk in genome-wide association studies. The underlying biological mechanism through which germline genetic variation in RAD51B confers susceptibility to breast cancer is not well understood. Here we investigate the molecular functi...
ORGANISM(S): Homo sapiens 
2014-04-22 | E-GEOD-56940 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Drosophila melanogaster ablated mushroom bodies vs unablated MB to investigate the repertoire of MB genes that control initiation and maintenance of neural differentiation during learning and memory
Mushroom bodies (MBs) are the centers for olfactory associative learning and elementary cognitive functions in the Drosophila brain. To get insights of the repertoire of MB genes that control initiation and maintenance of neural differentiation as well as the repertoire of neural factors that may h...
ORGANISM(S): Drosophila melanogaster 
2007-11-01 | E-GEOD-3379 | biostudies-arrayexpress
no omics definedTranscription profiling of three strains of fisson yeast treated with hydroxyurea for different lengths of time
Genome-wide analyses reveal checkpoint independence of most DNA replication origins during replication stress and re-replication in S. pombe
ORGANISM(S): Schizosaccharomyces pombe 
2007-11-16 | E-MEXP-1127 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse lymphoma L5178Y cells treated with Hydroxyurea
The multi-lab International Life Sciences Institute (ILSI) project on the application of genomics to risk assessment offered the unique opportunity to investigate the influence of variability within and between laboratories on identifying biologically relevant gene expression changes. We assessed th...
ORGANISM(S): Mus musculus 
2005-08-25 | E-TOXM-17 | biostudies-arrayexpress
GenomicsMulticenter Study of Hydroxyurea (MSH)
Multicenter Study of Hydroxyurea (MSH)
PRJNA701327 | ENA
GenomicsMulticenter Study of Hydroxyurea (MSH)
Multicenter Study of Hydroxyurea (MSH)
PRJNA701326 | ENA
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