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MetabolomicsSphingolipid-dependent Dscam sorting regulates axon segregation
Neurons are highly polarized cells with distinct protein compositions in axonal and dendritic compartments. Cellular mechanisms controlling polarized protein sorting have been described for mature nervous system but little is known about the segregation in newly differentiated neurons. In a forward ...
2019-03-29 | MTBLS825 | MetaboLights
MetabolomicsMetabolomics dataset of optogenetic axon regenerative mouse model post optic nerve crush
Not available
ORGANISM(S): Mus musculus 
ST002111 | MetabolomicsWorkbench
TranscriptomicsIdentification of a microRNA regulator for axon guidance in the olfactory bulb of adult mice
Using the highly sensitive miRNA array, we screened 40 microRNAs abundant in the olfactory bulb and we explored the functions of these miRNAs in the olfactory bulb by Gene Ontology and Kyoto Encyclopedia of Genes annotation. The enrichment results indicated that these miRNAs mainly participated in t...
ORGANISM(S): Mus musculus 
2014-08-27 | E-GEOD-55463 | biostudies-arrayexpress
GenomicsSEMA3B switches axon-axon to axon-glia interactions required for unmyelinated axon envelopment and integrity
SEMA3B switches axon-axon to axon-glia interactions required for unmyelinated axon envelopment and integrity
PRJNA1248491 | ENA
ProteomicsCentrosome-mediated microtubule remodeling during axon formation in human iPSC-derived neurons
Local microtubule remodeling is critical for axon formation, the first step in establishing neuronal polarity. However, the function of the microtubule organizing centrosomes during the onset of axon formation, is still under debate. Here, we demonstrate that centrosomes play an essential role in co...
ORGANISM(S): Homo sapiens (Human) 
2021-02-12 | PXD020221 | Pride
Centrosome  axon  development  human  hipsc-derived neuron 
TranscriptomicsTranscription profiling of Drosophila mushroom body neurons at the onset and early steps of axon pruning
Drosophila mushroom body (MB) γ neurons undergo axon pruning during metamorphosis through a process of localized degeneration of specific axon branches. Developmental axon degeneration is initiated at the onset of metamorphosis by the pre-pupal rise in the steroid hormone ecdysone. This study ide...
ORGANISM(S): Drosophila melanogaster 
2008-06-18 | E-GEOD-10012 | biostudies-arrayexpress
ProteomicsUnbiased proteomic study of the axons of cultured rat cortical neurons
We have conducted quantitative proteomic analyses of the axons of cultured rat cortical neurons. Axons are isolated by using glass chips that enable the axons and their cell bodies of neurons to grow in separated regions on the chip surface. Proteins extracted from the isolated axons, as well as tho...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-04-17 | PXD005527 | Pride
Rat Axon Label-free quantification 2d-lc-msms Dimethyl-labeling quantitative proteomics 
ProteomicsStructural plasticity of actin-spectrin membrane skeleton and functional role of actin and spectrin in axon degeneration
Axon degeneration sculpts precise patterns of connectivity in the developing nervous system and is an early pathological hallmark of several adult-onset neurodegenerative disorders. Substantial progress has been made in identifying effector mechanisms that drive axon fragmentation, but far less is k...
ORGANISM(S): Mus musculus (Mouse) 
2019-03-14 | PXD009854 | Pride
Proteomics Axon degeneration Phosphorylation 
GenomicsAxon-enriched lincRNA ALAE is required for axon elongation via regulating local mRNA translation
Axon-enriched lincRNA ALAE is required for axon elongation via regulating local mRNA translation
PRJNA636646 | ENA
TranscriptomicsTranscription profiling of Drosophila mutant and wild type embryos toinvestigate axon guidance
During the development of the Drosophila central nervous system the process of midline crossing is orchestrated by a number of guidance receptors and ligands. Many key axon guidance molecules have been identified in both invertebrates and vertebrates, but the transcriptional regulation of growth co...
ORGANISM(S): Drosophila melanogaster 
2008-06-15 | E-GEOD-6515 | biostudies-arrayexpress
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