Sort   by:  
 Page size 
TranscriptomicsCentrosome amplification is sufficient to promote spontaneous tumorigenesis in mammals
Centrosome amplification is a common feature of human tumors, but whether this is a cause or a consequence of human cancer remains unclear. Here, we report the creation of a mouse model in which centrosome number can be persistently increased in the absence of additional genetic defects. We show tha...
ORGANISM(S): Mus musculus 
2017-02-04 | E-MTAB-5043 | biostudies-arrayexpress
GenomicsCentrosome amplification triggers tumorigenesis in p53 deficient epidermis
While aneuploidy is found in more than 90% of solid tumors, it is unclear whether aneuploidy is the cause or the consequence of tumorigenesis. Different mouse models deficient in centrosomal or spindle checkpoint proteins that induce aneuploidy show either a promotion or a decrease in tumorigenesis ...
ORGANISM(S): Mus musculus 
2015-10-27 | E-MTAB-3733 | biostudies-arrayexpress
ProteomicsSpatial centrosome proteome of human neural cells uncovers novel interactors and disease hubs
Despite the crucial importance of the centrosome in brain development and disease, its comprehensive proteome remains uncharacterized in neural cells. Here, we used spatial proteomics to elucidate protein interaction networks at the centrosome of iPSC-derived human neural stem cells (NSCs) and neuro...
ORGANISM(S): Homo sapiens (Human) 
2022-06-22 | PXD031936 | Pride
Neuron Neural stem cells Neurodevelopmental disorder Human brain Rna splicing Centrosome Interactome 
TranscriptomicsMolecular Signature of Centrosome Abnormalities in Multiple Myeloma
A large number of cancer-associated proteins involved in the cell cycle, DNA repair, chaperoning and nucleocytoplasmic transport etc. are involved in the control of centrosome number, duplication, centrosome formation and have been implicated as origin of centrosome abnormalities in cancer. In this ...
ORGANISM(S): Homo sapiens 
2013-03-21 | E-MTAB-1038 | biostudies-arrayexpress
GenomicsRNA-seq of cells with centrosome amplification
RNA-seq of cells with centrosome amplification
PRJEB48608 | ENA
ProteomicsPCNA and JNK1-Stat3 pathways respectively promotes and inhibits centrosome amplification by targeting at the ROCK1/14-3-3σ complex
We have recently reported that type 2 diabetes promotes cell centrosome amplification via enhancing the expression, biding and centrosome translocation of ROCK1/14-3-3σ complex. In the present functional proteomic study, we further investigated the molecular pathways underlying the centrosome amplif...
ORGANISM(S): Homo Sapiens 
2018-03-30 | PXD009370 |
ProteomicsSILAC analysis of exosome secretion in response to centrosome amplification
We performed quantitative proteomics analysis by Stable Isotope Labelling by Amino Acids in Cell culture (SILAC) to understand how centrosome amplification changes the composition of human small extracellular vesicles. We carried out SILAC labelling with medium and heavy isotopes, as it enables the ...
ORGANISM(S): Homo sapiens (Human) 
2021-01-19 | PXD020984 | Pride
Exosomes Small extracellular vesicles. Centrosome amplification Silac 
ProteomicsProteomic analysis of centrosome-associated proteins between non-activated non-polarized and activated polarized murine B cells R#1 (R#2 doi: 10.1038/ncomms10969) & R#3
Using stable isotope labelling by amino acids in cell culture (SILAC)-based quantitative proteomics on purified centrosomes from resting, non-activated non-polarized, and activated polarized mouse B cells, we established a list of proteins differentially associated with the centrosome between restin...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-12 | PXD038725 | Pride
Centrosome Polarity B cells Antigen stimulation 
TranscriptomicsGene expression in mitotic tissues of Drosophila larvae without centrosomes or too many centrosomes
Centrosome defects are a common feature of many cancers. Surprisingly, flies can proceed through the majority of development without centrosomes or with amplified centrosomes in most of their cells. It is unclear whether this is because centrosome defects do not cause many problems in Drosophila cel...
ORGANISM(S): Drosophila melanogaster 
2012-08-20 | E-GEOD-35240 | biostudies-arrayexpress
ProteomicsCEP44 ensures the formation of bona fide centriole wall, a requirement for the centriole-to-centrosome conversion
The centriole-to-centrosome conversion is a mechanism of the centrosome maturation process that depends on the formation of a proper centriole wall structure. Beside the centriole wall biogenesis factors TUBD1 and TUBE1, CEP44 is involved in this process. Lack of CEP44 generates defects in the centr...
ORGANISM(S): Homo sapiens (Human) 
2020-03-24 | PXD017332 | Pride
Human Centriol-to-centrosome conversion Poc1b Centrosome Cep44 
Sort   by:  
 Page size