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TranscriptomicsThe exon junction complex regulates the splicing of cell polarity gene dlg1 to control Wingless signaling in development
Wingless (Wg)/Wnt signaling is conserved in all metazoan animals and plays critical roles in development. The Wg/Wnt morphogen reception is essential for signal activation, whose activity is mediated through the receptor complex and a scaffold protein Dishevelled (Dsh). We report here that the exon ...
ORGANISM(S): Drosophila melanogaster 
2016-08-19 | E-GEOD-81220 | biostudies-arrayexpress
TranscriptomicsA genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers
In a genome-wide screen of human cancer cell lines, we identified homozygous intragenic microdeletions involving genes encoding components of the apical-basal cell polarity complexes. Among these, PARD3 is disrupted in cell lines and primary tumors from squamous carcinomas and glioblastomas. Reco...
ORGANISM(S): Homo sapiens 
2011-11-03 | E-GEOD-20306 | biostudies-arrayexpress
GenomicsBEAF-32 insulator regulates gene expression of genes involved in cell polarity and neoplastic growth.
This SuperSeries is composed of the following subset Series: GSE36735: Distribution of Drosophila insulator protein BEAF-32 in Wing imaginal tissue (Wildtype) [ChIP-seq] GSE36736: Genome wide transcriptional profiling of BEAF-32 in wing imaginal tissues of wildtype and mutants [expresion array] Refe...
ORGANISM(S): Drosophila melanogaster 
2012-07-05 | E-GEOD-36737 | biostudies-arrayexpress
ModelsVu2019 - Planarian tissue polarity
The model explores the establishment and stability of the wildtype polarity pattern in planarian flatworms. Initial conditions for A and M fields are chosen as arbitrarily perturbed to demonstrate stability of the wild type pattern. A represents the A/P polarization system, M represents the M/L pola...
2021-10-05 | MODEL2107170001 | BioModels
ModelsvonDassow2000 - Segment Polarity Network model on 1x4 grid of cells
This is the segment polarity network model described by von Dassow et al. (2000). It represents a toroidal hexagonal array of cells (1x4), where each cell can express various genes (wingless engrailed, hedgehog, cubitus interruptus, and patched) and where their protein products interact within a cel...
2025-01-08 | BIOMD0000001065 | BioModels
ProteomicsPlanar Cell Polarity Core Protein Vangl
Vangl is a planar cell polarity (PCP) core protein essential for aligned cell orientation along the epithelial plane perpendicular to the apical-basal direction, which is important for tissue morphogenesis, development and collective cell behavior.
ORGANISM(S): Homo Sapiens 
PXD054233 |
TranscriptomicsCTCF binding polarity determines chromatin looping [4C]
CCCTC-binding factor (CTCF) is an architectural protein involved in the three-dimensional organization of chromatin. In this study, we systematically assayed the 3D genomic contact profiles of hundreds of CTCF binding sites in multiple tissues with high-resolution 4C-seq. We find both developmentall...
ORGANISM(S): Mus musculus 
2015-10-29 | E-GEOD-72539 | biostudies-arrayexpress
ProteomicsMyc and the Tip60 chromatin remodeling complex control neuroblast maintenance and polarity in Drosophila
Stem cells establish cortical polarity and divide asymmetrically to simultaneously maintain themselves and generate differentiating offspring cells. Several chromatin modifiers have been identified as stemness factors in mammalian pluripotent stem cells, but whether these factors control stem cell p...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2018-07-06 | PXD009939 | Pride
Neuroblast Stem cell Chromatin remodeling Asymmetric cell division Polarity 
GenomicsDistribution of Drosophila insulator protein BEAF-32 in Wing imaginal tissue (Wildtype) [ChIP-seq]
Chromatin insulators are DNA protein complexes that mediate inter and intra chromosomal interactions. Boundary Element Associated Factor- 32 (BEAF-32) is an insulator protein predominantly found near gene promoters and thought to play a role in gene expression. We find that mutations in BEAF-32 are ...
ORGANISM(S): Drosophila melanogaster 
2012-07-05 | E-GEOD-36735 | biostudies-arrayexpress
ProteomicsBasolateral Protein Scribble Provides Phosphatase PP1 to a Signaling Network Maintaining Apicobasal Polarity
Scribble, a member of the LAP protein family, contributes to the apicobasal polarity (ABP) of epithelial cells. The LAP unique region (LUR) of these proteins is essential for ABP function, and includes a highly conserved Leucine Reach Repeat (LRR) domain. Here we study how the LRR domain of Scribble...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD028919 | Pride
Scribble Apicobasal polarity Phosphatase pp1 
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