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ProteomicsBasolateral Protein Scribble Provides Phosphatase PP1 to a Signaling Network Maintaining Apicobasal Polarity
Scribble, a member of the LAP protein family, contributes to the apicobasal polarity (ABP) of epithelial cells. The LAP unique region (LUR) of these proteins is essential for ABP function, and includes a highly conserved Leucine Reach Repeat (LRR) domain. Here we study how the LRR domain of Scribble...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD028919 | Pride
Scribble Apicobasal polarity Phosphatase pp1 
GenomicsYap1-Scribble polarization is required for hematopoietic stem cell division and fate
Yap1-Scribble polarization is required for hematopoietic stem cell division and fate
PRJNA635915 | ENA
TranscriptomicsYap1-Scribble polarization is required for hematopoietic stem cell division and fate
Yap1 and its paralogue Taz largely control epithelial tissue growth. We have identified that hematopoietic stem cell (HSC) fitness response to stress depends on Yap1 and Taz. Deletion of Yap1 and Taz induces a loss of HSC quiescence, symmetric self-renewal ability and renders HSC more vulnerable to ...
ORGANISM(S): Mus musculus 
2020-05-30 | GSE151465 | GEO
UnknownViral subversion of the cell polarity regulator Scribble.
Not available
S-EPMC9987997 | biostudies-literature
UnknownScribble Scaffolds a Signalosome for Active Forgetting.
Not available
S-EPMC4926877 | biostudies-literature
UnknownScribble and α-Catenin cooperatively regulate epithelial homeostasis and growth.
Not available
S-EPMC9532510 | biostudies-literature
TranscriptomicsIdentifying genes differentially expressed in MDCK cells with scribble knock-down (scribKD)
Aim: To identify genes and pathways involved in elimination of scribKD cells by competition. Methods: We carried out mRNA sequencing of MDCK-II cells carrying a tetracycline-inducible scribble shRNA construct.
ORGANISM(S): Canis lupus familiaris 
2017-02-09 | GSE79042 | GEO
UnknownRole of the polarity protein Scribble for podocyte differentiation and maintenance.
Not available
S-EPMC3346764 | biostudies-literature
UnknownScribble interacts with beta-catenin to localize synaptic vesicles to synapses.
Not available
S-EPMC2710836 | biostudies-literature
UnknownScribble deficiency mediates colon inflammation by inhibiting autophagy-dependent oxidative stress elimination.
Not available
S-EPMC10603050 | biostudies-literature
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