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MetabolomicsMethionine cycle in C. elegans serotonergic neurons regulates diet-dependent behaviour and longevity through neuron-gut signaling

The folate and methionine cycles (Met-C) are regulated by vitamin B12 (B12), obtained exclusively from diet and microbiota. Met-C supports amino acid, nucleotide, and lipid biosynthesis and provides one-carbon moieties for methylation reactions. While B12 deficiency and polymorphisms in Met-C gen...

2025-07-05 | MTBLS12457 | MetaboLights
GenomicsSTAT3 promotes motor neuron differentiation by collaborating with motor neuron-specific LIM complex
The motor neuron (MN)–hexamer complex consisting of LIM homeobox 3, Islet-1, and nuclear LIM interactor is a key determinant of motor neuron specification and differentiation. To gain insights into the transcriptional network in motor neuron development, we performed a genome-wide ChIP-sequencing an...
ORGANISM(S): Mus musculus 
2013-09-19 | E-GEOD-50993 | biostudies-arrayexpress
TranscriptomicsToxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss
FUS is an RNA-binding protein involved in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Cytoplasmic FUS-containing aggregates are often associated with concomitant loss of nuclear FUS. Whether loss of nuclear FUS function, gain of a cytoplasmic function, or a combination of ...
ORGANISM(S): Mus musculus 
2016-03-14 | E-GEOD-78730 | biostudies-arrayexpress
ProteomicsDiscovery of novel markers for identifying cognitive decline from neuron-derived exosomes
Alzheimer’s disease (AD), the predominant cause of late-life dementia, has a multifactorial etiology. Since there are few therapeutic options for symptomatic AD, research is increasingly focused on the identification of pre-symptomatic biomarkers. Recently, evaluation of neuron-derived exosomal mark...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027561 | Pride
Mci Proteomics Neuron derived exosome 
ProteomicsNeuron-Microglia Protein Transfer
Analysis of BONCAT-labeled, Neuron-derived proteins inside of microglia.
ORGANISM(S): Mus musculus (Mouse) 
2025-11-07 | PXD066030 | Pride
Boncat Neuron Protein transfer Microglia 
UnknownA computational model of motor neuron degeneration.
Not available
S-EPMC4167823 | biostudies-literature
TranscriptomicsIdentification of genes expressed with temporal-spatial restriction to developing cerebellar neuron precursors by a functional genomic approach perspective of human cancers.
Swiss-Webster B mouse postnatal day 4-5 primary cerebellar culture (pooled from litter mates) treated with sonic hedgehog (Shh), controls (veh), growth arrested (arrest), cycloheximide (cyc) for 1, 3 and 24 hours. Different treatment conditions with biological replicates. Mouse cerebellar granule ce...
ORGANISM(S): Mus musculus 
2013-09-06 | E-GEOD-50606 | biostudies-arrayexpress
TranscriptomicsAge-associated bidirectional modulation of gene expression in single identified R15 neuron of Aplysia
Despite the advances in our understanding of aging-associated behavioral decline, we know relatively little about how aging affect neural circuits that underlie specific behaviors. Specifically, we know little about how aging affect expression of genes in specific neural circuits. We have now addres...
ORGANISM(S): Aplysia californica 
2014-02-05 | E-GEOD-46618 | biostudies-arrayexpress
Transcriptomics1,25-dihydroxyvitamin D3-induced genes in mouse mixed neuron-glial cell cultures
Transcriptomic response of mouse mixed neuron-glial cell cultures to 1,25-dihydroxyvitamin D3 6 samples are analysed with three biological replicates in two conditions, control versus 1,25-dihydroxyvitamin D3 (1,25(OH)2D3)
ORGANISM(S): Mus musculus 
2013-03-25 | E-GEOD-41184 | biostudies-arrayexpress
ProteomicsLiver Steatosis and Mitochondrial Dysfunction in Spinal Muscular Atrophy is Survival Motor Neuron-Dependent and Hepatocyte-Intrinsic
Spinal Muscular Atrophy (SMA) is typically characterized as a motor neuron disease, but extra-neuronal phenotypes are present in almost every organ in severely affected patients and animal models. Extra-neuronal phenotypes were previously underappreciated as patients with severe SMA phenotypes usual...
ORGANISM(S): Homo Sapiens (human) 
2024-05-09 | PXD045401 | JPOST Repository
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