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ProteomicsIn-depth site-specific O-glycosylation analysis of glycoproteins and endogenous peptides in cerebrospinal fluid (CSF) from healthy individual mild cognitive impairment (MCI) and Alzheimer disease (AD) patients
Site-specific O-glycoproteome mapping in complex biological system provides molecular basis for understanding the structure-function relationships of glycoproteins and their roles in physiological and pathological processes. Previous O-glycoproteome analysis in cerebrospinal fluid (CSF) focused on s...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-04-05 | MSV000087160 | MassIVE
GenomicsMCI and gut microbiome
Modulation of the gut microbiome in Mild Cognitive Impairment (MCI) subjects
PRJEB32675 | ENA
ProteomicsLC-MS/MS Isomeric Profiling of N-Glycans derived from Low-Abundant Serum Glycoproteins in Mild Cognitive Im-pairment Patients
Mild cognitive impairment (MCI) is an early stage of memory loss that affects cognitive abilities, such as language or virtual/spatial comprehension. This cognitive decline is mostly ob-served with the aging of individuals. Recently, MCI has been considered as a prodromal phase of Alzheimer’s diseas...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD036704 | Pride
Mci Biomarker glycan Neurological disorder Isomeric n-glycans 
MetabolomicsUrine metabolomics phenotyping and urinary biomarker exploratory in mild cognitive impairment and Alzheimer's disease.

INTRODUCTION Alzheimer's disease is a prevalent disease with a heavy global burden and is suggested to be a metabolic disease in the brain in recent years. The metabolome is considered to be the most promising phenotype which reflects changes in genetic, transcript, and protein ...

2024-01-11 | MTBLS8662 | MetaboLights
GenomicsGenome-wide mRNA profiling of Edaravone (MCI-186) effects in human induced pluripotent stem cells-derived motor neurons
Genome-wide mRNA profiling of Edaravone (MCI-186) effects in human induced pluripotent stem cells-derived motor neurons
PRJNA638033 | ENA
ProteomicsComprehensive and Unbiased Plasma Proteomics with Proteograph
Mild Cognitive Impairment (MCI) is a precursor to Alzheimer's disease (AD), necessitating early identification through reliable markers. We employed ProteographTM, an automated platform utilizing nanoparticles coupled with a liquid chromatography-tandem mass spectrometry (LC-MS/MS) workflow, enablin...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD067951 | Pride
Proteograph Mild cognitive impairment Human plasma 
GenomicsRNA sequencing of AD, MCI and control OM cells
Total RNA sequencing of cultured OM cells derived from patients with Alzheimer's disease (AD), individuals with mild cognitive impairment (MCI) and cognitively healthy controls.
EGAS00001006195 | EGA
TranscriptomicsGenome-wide mRNA profiling of Edaravone (MCI-186) effects in human induced pluripotent stem cells-derived motor neurons
In this study, we used human motor neurons derived from induced pluripotent stem cell lines (N1) to identify universal transcriptomic signatures of MCI-186 cellular effects, to highlight novel pathways responsible for its biological activity, and to unravel potential molecular actions in amyotrophic...
ORGANISM(S): Homo sapiens 
2021-06-01 | GSE151997 | GEO
GenomicsRNA sequencing of AD, MCI and control ONS cells
We have generated human olfactory neurosphere-derived (ONS) cells from individuals with AD or mild cognitive impairment (MCI), and their cognitively healthy controls, and performed global RNA sequencing to determine gene expression changes in ONS cells.
EGAS00001006594 | EGA
UnknownBiodegradation of different PET variants from food containers by Ideonella sakaiensis.
Not available
S-EPMC9668955 | biostudies-literature
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