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ProteomicsHuman Bone Marrow Interstitial Fluid Plasma Cell Dyscrasias LC-MSMS
Bone Marrow Interstital Fluid from 120 patients with various plasma cell dyscrasias were assessed using Seer's Proteograph XT platform and an LC-MS system. For each sample, two MS injections were performed, one for each nanoparticle incubation used in the Proteograph XT.
ORGANISM(S): Homo sapiens (Human) 
2025-10-21 | PXD059339 | Pride
Lc-msms Bone marrow interstitial fluid Multiple myeloma 
ProteomicsMultiplexed Nanoparticle Protein Corona Enables Accurate and Precise Deep Plasma Proteomics
The Proteograph Product Suite, a multiplexed nanoparticle (NP) protein corona-based proteomics workflow, substantially improves the depth of detection of proteins by mass spectrometry (MS) by compressing the dynamic range of protein abundances. Here, we explore the quantitative performance of the Pr...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2025-10-22 | PXD066813 | Pride
Lc-ms Plasma proteomics Precision Nanoparticle Protein corona Quantification accuracy Proteograph product suite 
ProteomicsMultiplexed Nanoparticle Protein Corona Enables Accurate and Precise Deep Plasma Proteomics
The Proteograph Product Suite, a multiplexed nanoparticle (NP) protein corona-based proteomics workflow, substantially improves the depth of detection of proteins by mass spectrometry (MS) by compressing the dynamic range of protein abundances. Here, we explore the quantitative performance of the Pr...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2025-10-22 | PXD066700 | Pride
Lc-ms Plasma proteomics Precision Nanoparticle Protein corona Quantification accuracy Proteograph product suite 
ProteomicsMultiplexed Nanoparticle Protein Corona Enables Accurate and Precise Deep Plasma Proteomics
The Proteograph Product Suite, a multiplexed nanoparticle (NP) protein corona-based proteomics workflow, substantially improves the depth of detection of proteins by mass spectrometry (MS) by compressing the dynamic range of protein abundances. Here, we explore the quantitative performance of the Pr...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2025-10-22 | PXD066817 | Pride
Lc-ms Plasma proteomics Precision Nanoparticle Protein corona Quantification accuracy Proteograph product suite 
ProteomicsProteograph™-Based Proteome and Sphingolipidome Analysis for Serological Biomarker Discovery in Long-Duration Space Mission
Introduction: Exposure to microgravity for 180 days leads to significant muscle mass and strength loss, which current countermeasures only partially mitigate. This study aimed to identify novel serological biomarkers to monitor muscle tissue adaptations during and after spaceflight. Serum samples fr...
ORGANISM(S): Homo sapiens (Human) 
2026-05-13 | PXD069732 | Pride
Glucosylceramide Serological biomarkers Spaceflight serum biomarkers Serum proteomics Sphingolipidomics Proteograph Long-duration space mission Hdl-binding protein (hdlbp) 
ProteomicsA proteogenomics study using the Seer Proteograph platform
In recent years, the development of molecular clocks has provided avenues for estimation of biological age. Traditionally, methylation-based epigenetic clocks have been the focus of age predictor developments, however individual proteomics, transcriptomics, and ATAC-Seq have provided avenues for oth...
ORGANISM(S): Homo sapiens (Human) 
2025-09-29 | PXD048709 | Pride
Gwas Proteomics Mass spectrometry Genome-wide association studies Protein quantitative trait loci Pqtl Proteograph™ workflow 
ProteomicsComprehensive and Unbiased Plasma Proteomics with Proteograph
Mild Cognitive Impairment (MCI) is a precursor to Alzheimer's disease (AD), necessitating early identification through reliable markers. We employed ProteographTM, an automated platform utilizing nanoparticles coupled with a liquid chromatography-tandem mass spectrometry (LC-MS/MS) workflow, enablin...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD067951 | Pride
Proteograph Mild cognitive impairment Human plasma 
UnknownA genome-wide association study of mass spectrometry proteomics using the Seer Proteograph platform.
Not available
S-EPMC11160678 | biostudies-literature
ProteomicsComparison of deep plasma proteome enrichment methods
Plasma is a complex biological fluid containing extracellular vesicles (EVs), residual platelets, and soluble proteins, all of which can serve as biomarkers for pathological conditions. While conventional plasma proteomics typically identifies hundreds of proteins, recent enrichment strategies have ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-17 | PXD063673 | Pride
Enrichplus Proteograph Magnet Timstof Enrichment Plasma Evs Lc-ms/ms 
ProteomicsNanoparticle Enrichment Mass-Spectrometry Proteomics Identifies Protein Altering Variants for Precise pQTL Mapping
Proteogenomics studies generate hypotheses on protein function and provide genetic evidence for drug target prioritization. Most previous work has been conducted using affinity-based proteomics approaches. These technological face challenges, such as uncertainty regarding target identity, non-specif...
ORGANISM(S): Homo sapiens (Human) 
2023-12-19 | PXD042852 | Pride
Protein altering variants Proteomics Protein quantitative trait loci Mass spectrometry Genome-wide association studies Proteograph™ workflow 
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