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MetabolomicsInvestigating the Mechanisms of Silver Nanoparticle Toxicity in Daphnia magna: A Multi-Omics Approach
Silver nanoparticles (AgNPs), one of the most common nanomaterials in use today, have been shown to enter the aquatic environment from use of commercially obtained products. Although acute toxicity has been shown in vitro and in vivo, there is still a great deal of uncertainty surrounding the molecu...
2017-05-08 | MTBLS260 | MetaboLights
MetabolomicsUntargeted Metabolomics Study of Cur-EGCG Self-Assembled Nanoparticle Systems in Intervening WSSV Infection in Crayfish
This study employed Untargeted LC-MS/MS metabolomics to analyze changes in the metabolic profile of crayfish following WSSV infection after intervention with the Cur-EGCG self-assembled nanoscale system (CE SA). The experiment included WSSV and CE SA treatment groups. Through multivariate statistica...
2026-10-04 | MTBLS15908 | MetaboLights
MetabolomicsBiological Effects of Amphiphilic Copolymer Nanoparticle-Encapsulated Multi-target Chemotherapeutic Drugs on MCF-7 Human Breast Cancer Cells
INTRODUCTION: Amphiphilic copolymer nanoparticle-encapsulated multi-target chemotherapeutic drugs have attracted considerable attention due to their favorable drug efficiency and potential application prospect. Studies have shown that an amphiphilic copolymer, methoxypoly(ethylene glycol)-poly(lacti...
2018-05-03 | MTBLS430 | MetaboLights
ProteomicsNanoparticle-enabled plasma proteomics of a preclinical atherosclerosis model reveals common signatures with human disease
Coronary heart disease (CHD) accounts for one-third of deaths in the United States, with an annual economic burden exceeding $400 billion. Elevated plasma levels of low-density lipoprotein-cholesterol (LDL-C) is a major risk factor for CHD, through its promotion of atherosclerosis. Mutations in the ...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-20 | PXD063218 | Pride
Plasma Atherosclerosis Dia Nanoparticle Proteomics 
ProteomicsHigh-throughput plasma/serum proteomics by coupling nanoparticle protein corona-based sample preparation and capillary zone electrophoresis-tandem mass spectrometry
A high-throughput workflow for bottom-up proteomics (BUP) of human plasma using capillary zone electrophoresis-tandem mass spectrometry (CZE-MS/MS) and nanoparticle protein corona-assisted sample preparation is presented. The streamlined approach enabled the identification and quantification of hun...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2025-08-04 | PXD063043 | Pride
Nanoparticle protein corona Bottom-up proteomics High-throughput Cze-ms/ms Biomarker 
TranscriptomicsGene Expression in Gold Nanoparticle Oligonucleotide Complexes treated Primary Immune Cells
Gold nanoparticle (Au—NP) oligonucleotide complexes hold considerable promise as an approach for manipulating intracellular gene regulation. We show that the uptake and intracellular fate of Au—NP oligonucleotide complexes is associated with endocytosis and signal transduction. A transcriptomeâ€...
ORGANISM(S): Homo sapiens 
2010-04-06 | E-GEOD-20677 | biostudies-arrayexpress
ProteomicsIdentification of Putative Kidney-Derived Proteins in Plasma using Nanoparticle Enrichment
Many diseases, including diabetes and hypertension, can lead to kidney damage, often resulting in long-term health complications and organ failure. Both animal and human studies have documented a causal relationship between high dietary sodium intake and elevated blood pressure. We explored a proteo...
ORGANISM(S): Papio hamadryas 
2026-03-30 | PXD071248 | Pride
Lc-msms Plasma Tissue-leakage proteins Diet challenge Kidney Baboon Non-human primates Sodium Nanoparticle affinity enrichment 
TranscriptomicsComparative Iron Oxide Nanoparticle Cellular Dosimetry and Response in Mice by the Inhalation and Liquid Cell Culture Exposure Routes
To identify the molecular impact of SPIO nanoparticle inhalation exposure on lung tissue. Transcriptional responses were measured by global microarray analysis of mouse lung. Male Balb/c mice were exposed to aerosolized SPIO nanoparticles using a nano-aerosol generation and inhalation system . Expos...
ORGANISM(S): Mus musculus 
2014-04-15 | E-GEOD-51417 | biostudies-arrayexpress
TranscriptomicsAntivirulence activities of zinc ion and ZnO nanoparticle against Pseudomonas aeruginosa
An antivirulence approach targets bacterial virulence rather than cell viability in the antibiotic approach that can readily lead to drug resistance. Opportunistic human pathogen Pseudomonas aeruginosa produces a variety of virulence factors, and biofilm cells of this bacterium are much more resista...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2015-05-25 | E-GEOD-46947 | biostudies-arrayexpress
ProteomicsNanoparticle Elasticity Affects Systemic Circulation lifetime by Modulating the Adsorption of Apolipoprotein A-I in Corona Formation
Nanoparticle elasticity plays crucial roles in determining nanoparticles’ physiological performances. However, the underlying mechanisms by which nanoparticle elasticity does so remain unknown.Using core-shell nanoparticles with a same PEGylated lipid bilayer shell yet cores differing in elasticity ...
ORGANISM(S): Mus Musculus 
2022-05-20 | PXD034004 |
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