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ProteomicsComparison of deep plasma proteome enrichment methods
Plasma is a complex biological fluid containing extracellular vesicles (EVs), residual platelets, and soluble proteins, all of which can serve as biomarkers for pathological conditions. While conventional plasma proteomics typically identifies hundreds of proteins, recent enrichment strategies have ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-17 | PXD063673 | Pride
Enrichplus Proteograph Magnet Timstof Enrichment Plasma Evs Lc-ms/ms 
ProteomicsImpact of variations in standard operating procedure on plasma proteome recovery
Advancements in mass spectrometry and complementary technologies now enable comprehensive and high-resolution plasma proteomics. Plasma is a key biofluid for clinical research, harboring potential disease informative biomarkers. Commercial sources of non-diseased, healthy donor plasma samples are of...
ORGANISM(S): Homo sapiens (Human) 
2026-04-13 | PXD069325 | Pride
Mass spectrometry Clinical proteomics Biofluids Data-independent acquisition 
ProteomicsImpact of variations in standard operating procedure on plasma proteome recovery
Advancements in mass spectrometry and complementary technologies now enable comprehensive and high-resolution plasma proteomics. Plasma is a key biofluid for clinical research, harboring potential disease informative biomarkers. Commercial sources of non-diseased, healthy donor plasma samples are of...
ORGANISM(S): Homo sapiens (Human) 
2026-04-13 | PXD069212 | Pride
Mass spectrometry Clinical proteomics Biofluids Data-independent acquisition 
ProteomicsAutomated MagNet Enrichment Unlocks Deep and Cost-Effective LC-MS Plasma Proteomics
Plasma is an ideal material for proteomics due to its diverse protein content reflecting physiological and pathological states, and its compatibility with minimally invasive sampling. Deep proteomic profiling of plasma is limited by high-abundant proteins that mask the detection of low-abundant prot...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-05-05 | MSV000097796 | MassIVE
ProteomicsA Technical Evaluation of Plasma Proteomics Technologies
We report a technical evaluation of six notable plasma proteomics technologies from recent years. Unenriched plasma, perchloric acid depletion, PreOmics ENRICHplus, Mag-Net, Seer Proteograph XT, and Olink Explore HT. The methods were compared on proteomic depth, reproducibility, linearity, tolerance...
ORGANISM(S): Homo sapiens (Human) Gallus gallus (Chicken) 
2025-05-12 | PXD060573 | Pride
Plasma Lc-ms Proteomics 
ProteomicsA Technical Evaluation of Plasma Proteomics Technologies
We report a technical evaluation of six notable plasma proteomics technologies from recent years. Unenriched plasma, perchloric acid depletion, PreOmics ENRICHplus, Mag-Net, Seer Proteograph XT, and Olink Explore HT. The methods were compared on proteomic depth, reproducibility, linearity, tolerance...
ORGANISM(S): Homo sapiens (Human) 
2025-05-12 | PAD000002 | Pride
Affinity proteomics O-link 
ProteomicsA Technical Evaluation of Plasma Proteomics Technologies
We report a technical evaluation of six notable plasma proteomics technologies from recent years. Unenriched plasma, perchloric acid depletion, PreOmics ENRICHplus, Mag-Net, Seer Proteograph XT, and Olink Explore HT. The methods were compared on proteomic depth, reproducibility, linearity, tolerance...
ORGANISM(S): Gallus Gallus (ncbitaxon:9031) Homo Sapiens (ncbitaxon:9606) 
2026-02-23 | MSV000100943 | MassIVE
ProteomicsBenchmarking plasma proteomics depletion and enrichment workflows prior to LC-MS/MS analysis
A plasma sample was prepared using multiple depletion and enrichment techniques in order to improve the depth of proteomics analyses.
ORGANISM(S): Homo sapiens (Human) 
2026-06-15 | PXD069187 | Pride
Astral Proteomics Depletion Plasma Enrichment 
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