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TranscriptomicsTranscription profiling of mouse NB N1E-115 cells with wildtype, overexpression, knockdown of neuroblastoma Tcof1
Genomewide analysis of gene expression associated with Tcof1 in mouse neuroblastoma. NB N1E-115 cells with wildtype, overexpression, knockdown of Tcof1.
ORGANISM(S): Mus musculus 
2007-11-06 | E-GEOD-1956 | biostudies-arrayexpress
ProteomicsThe effect of TCOF1 on renal cancer proteome
TCOF1 encodes treacle, a multifunctional protein involved in ribosome biogenesis, regulation of mitosis, proliferation, response to DNA damage, and apoptosis. TCOF1 mutations cause Treacher Collins syndrome, a rare genetic disorder leading to craniofacial malformations. The expression of TCOF1 is di...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-05-25 | PXD027601 | Pride
Tcof1 Renal cancer Treacle 
TranscriptomicsTranscription profiling of mouse E8.5 wild-type and 3 E8.5 Tcof1+/- littermate embryos (Treacher Collins Syndrome)
The object of this study was to identify genes transcriptionally upregulated and downregulated in response to Tcof1 haploin-sufficiency during mouse embryogensis Experiment Overall Design: Total RNA was extracted from 3 E8.5 wild-type and 3 E8.5 Tcof1+/- littermate embryos using the RNeasy Mini Pro...
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-10167 | biostudies-arrayexpress
TranscriptomicsMouse neuroblastoma Tcof1
Genomewide analysis of gene expression associated with Tcof1 in mouse neuroblastoma. NB N1E-115 cells with wildtype, overexpression, knockdown of Tcof1. Keywords: ordered
ORGANISM(S): Mus musculus 
2004-11-11 | GSE1956 | GEO
GenomicsTCOF1 DRIVES STEMNESS OF TRIPLE-NEGATIVE BREAST CANCER THROUGH KIT
TCOF1 DRIVES STEMNESS OF TRIPLE-NEGATIVE BREAST CANCER THROUGH KIT
PRJNA714127 | ENA
GenomicsThe effect of TCOF1 silencing in renal cancer cells
The effect of TCOF1 silencing in renal cancer cells
PRJNA1275013 | ENA
TranscriptomicsThe effect of TCOF1 silencing in renal cancer cells
TCOF1 is a nucleolar protein involved in ribosome biogenesis, response to DNA damage and oxidative stress. Clear cell renal cell cancer (ccRCC) is characterized by pronounced nucleolar pleomorphism which is utilized in the ccRCC tumor grading system. Here, we hypothesized that TCOF1 may contribute t...
ORGANISM(S): Homo sapiens 
2026-05-15 | GSE299580 | GEO
TranscriptomicsTCOF1 DRIVES STEMNESS OF TRIPLE-NEGATIVE BREAST CANCER THROUGH KIT
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with poor prognosis. The high malignancy of TNBC is contributed by its heterogeneity and enrichment of cancer stem cells. By performing multiomic profiling, we recently uncovered super-enhancer heterogeneity between breas...
ORGANISM(S): Homo sapiens 
2021-11-02 | GSE168835 | GEO
ProteomicsDynamic phosphorylation of TCOF1 controlled by CK2 and PPM1D regulates nucleolar condensation and RNA Polymerase I activity
The nucleolus is a membrane-less organelle essential for rRNA transcription and ribosome biogenesis, yet the mechanisms regulating its dynamic assembly remain incompletely understood. Here, we identify the phosphatase PPM1D as a key regulator of the nucleolar architecture via dephosphorylation of th...
ORGANISM(S): Homo sapiens (Human) 
2026-10-02 | PXD065997 | Pride
Tcof1 Nucleolus Condensation Rna polymerase i Phosphorylation 
GenomicsMus musculus
Mouse neuroblastoma Tcof1
PRJNA90903 | ENA
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