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TranscriptomicsExpression data from BAP1 depleted cells
The deubiquitinase BAP1 is a candidate tumor suppressor regulating cell proliferation in human and is required for development in Drosophila. BAP1 is assembled into high molecular weight transcriptional multi-protein complexes. In order to identify potential BAP1 target genes, global mRNA expression...
ORGANISM(S): Homo sapiens 
2010-11-05 | E-GEOD-23035 | biostudies-arrayexpress
ProteomicsO-GlcNAcylation of FOXK1 orchestrates the E2F pathway
Gene transcription is a highly regulated process, and deregulation of transcription factors activity underlie numerous pathologies including cancer. FOXK1 and FOXK2 (FOXK1/2) transcription factors have recently emerged as important regulators of cell metabolism, autophagy and cell differentiation. W...
ORGANISM(S): Homo sapiens (Human) 
2024-06-10 | PXD050014 | Pride
E2f pathway O-glcnacylation Foxk1 
ProteomicsPervasive Roles of Ubiquitination in Orchestrating the Deubiquitinase Activity and Function of the BAP1/ASXL2 Tumor Suppressor Complex
The tumor suppressor and deubiquitinase (DUB) BAP1 regulates chromatin-associated processes and is frequently mutated in various malignancies. BAP1 and its drosophila orthologue Calypso assemble DUB complexes with ASXL-1, -2, -3 paralogues and ASX respectively, and these cofactors are required for s...
ORGANISM(S): Homo sapiens (Human) 
2018-09-28 | PXD011124 | Pride
Histone h2ak119ub  deubiquitination Polycomb group proteins  bap1  calypso  asxl  cell proliferation 
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