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MetabolomicsFOXK1 and FOXK2 Promote Cardiomyocyte Proliferation and Heart Regeneration
Promoting the proliferation of endogenous cardiomyocytes represents a promising strategy for treating cardiac injuries. Identifying key factors that regulate cardiomyocyte proliferation can advance the development of novel therapies for heart regeneration. Here we identify that FOXK1 and FOXK2 act a...
2025-02-13 | MTBLS12191 | MetaboLights
ProteomicsO-GlcNAcylation of FOXK1 orchestrates the E2F pathway
Gene transcription is a highly regulated process, and deregulation of transcription factors activity underlie numerous pathologies including cancer. FOXK1 and FOXK2 (FOXK1/2) transcription factors have recently emerged as important regulators of cell metabolism, autophagy and cell differentiation. W...
ORGANISM(S): Homo sapiens (Human) 
2024-06-10 | PXD050014 | Pride
E2f pathway O-glcnacylation Foxk1 
GenomicsLive cell monitoring of periodic gene expression in synchronous human cells identifies forkhead genes involved in cell cycle control
We report the genome wide DNA binding patterns of wild type FOXK1 in asynchronous HeLa cells using chromatin precipitation followed by high-throughput sequencing (ChIP-seq). We find that FOXK1 is bound to the promoter of a number of cell cycle genes including the E2F binding partner TFDP1. This st...
ORGANISM(S): Homo sapiens 
2012-07-09 | E-GEOD-39138 | biostudies-arrayexpress
GenomicsComparative transcriptomic analysis of WT, FOXK1/2 KO, DKO cells and FOXK1 KO cells with reconstitution of several FOXK1 mutants
Comparative transcriptomic analysis of WT, FOXK1/2 KO, DKO cells and FOXK1 KO cells with reconstitution of several FOXK1 mutants
PRJNA634392 | ENA
GenomicsRNA-seq datasets from differentiating iHA-Foxk1 and Foxk1 KO mESCs in mesodermal conditions
RNA-seq datasets from differentiating iHA-Foxk1 and Foxk1 KO mESCs in mesodermal conditions
PRJNA836571 | ENA
GenomicsATAC-seq datasets from differentiating iHA-Foxk1 and Foxk1 KO mESCs in mesodermal conditions
ATAC-seq datasets from differentiating iHA-Foxk1 and Foxk1 KO mESCs in mesodermal conditions
PRJNA836430 | ENA
ProteomicsA lineage master regulator and cancer-selective partner transcription factor reprogram 3D chromatin topology to establish tumor-specific gene control
Lineage-determining transcription factors (TFs), such as p63 in epithelial tissues, establish normal tissue identity but can also drive carcinogenesis. The epigenetic basis for these divergent effects, however, is unclear. Here, we show that p63 reorganizes three-dimensional (3D) chromatin topology ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD073599 | Pride
P63 foxk1 
GenomicsExtensive profiling of Foxk1 binding in genomic DNA
Extensive profiling of Foxk1 binding in genomic DNA
PRJNA448767 | ENA
UnknownNatural antisense RNA Foxk1-AS promotes myogenic differentiation by inhibiting Foxk1 activity.
Not available
S-EPMC9158385 | biostudies-literature
ProteomicsComparative analysis of the proteome of CD4+ T lymphocyte from WT or FOXK1 KO mice
Foxk1 is a transcription factor described to be involved in metabolism control. To investigate its role in T cell activation, and characterize the molecular pathways modulated by Foxk1, we determined by quantitative mass spectrometry analysis, the proteomes of control and Foxk1-/- CD4+ T cells activ...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-31 | PXD064444 | Pride
Total proteome Foxk1 Mouse cd4+ t cells 
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