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MetabolomicsGut microbiota-derived 3-indoleacrylic acid mediates ferulic acid protection against aflatoxin B1 hepatotoxicity via AhR-ferroptosis inhibition

Aflatoxin B1 (AFB1)-induced hepatic inflammation poses severe global health burdens with limited interventions. Here, we demonstrated that ferulic acid (FA), a cereal-derived polyphenol, alleviated AFB1 hepatotoxicity by remodeling gut microbiota and activating microbial tryptopha...

2026-08-14 | MTBLS12942 | MetaboLights
MetabolomicsGut microbiota-derived 3-indoleacrylic acid mediates ferulic acid protection against aflatoxin B1 hepatotoxicity via AhR-ferroptosis inhibition

Given that Aflatoxin B1 exposure drives 5% to 28% of global hepatocellular carcinoma cases, the critical paucity of effective interventions for Aflatoxin B1-induced liver injury represents an urgent need. Here, we discover that a cereal-derived polyph...

2026-08-13 | MTBLS13667 | MetaboLights
TranscriptomicsYeast Genomic Expression Patterns of Wild-type and PTC1 null mutant in Response to Aflatoxin B1 (AFB1)
The evaluation of the toxicity of Aflatoxin B1 using yeast gene expressions. Two yeast strains; parental BY4743 and PTC1 mutant, were used for this study. SDS was used to raise the penetration of the yeast cell membrane. Two conditions are compared with three replicates each. Both strains were grown...
ORGANISM(S): Saccharomyces cerevisiae 
2010-04-12 | E-GEOD-17367 | biostudies-arrayexpress
TranscriptomicsDNA methylome analysis in infants from The Gambia / Aflatoxin / Seasonality study
Genome wide DNA methylation profiling in infant's blood from a mother/child cohort in The Gambia. The main variables of the analyses were the intra-uterine exposure to aflatoxin B1 (AFB1) and the season of conception. The Illumina Infinium HumanMethylation 450k Beadchip was used to obtain DNA methyl...
ORGANISM(S): Homo sapiens 
2015-04-18 | E-GEOD-59592 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse livers of adult and newborn animal response to Aflatoxin B1
Susceptibility to the hepatocarcinogen Aflatoxin B1 (AFB1) varies among species and with age. Mice are refractory to carcinogenic and toxic effects of AFB1; however, B6C3F1 mice show transient sensitivity if dosed shortly after birth. We compared age-related differences in gene expression and trans...
ORGANISM(S): Mus musculus 
2009-01-14 | E-GEOD-4740 | biostudies-arrayexpress
TranscriptomicsDifferential expression of Aspergillus genes during the induction of aflatoxin biosynthesis
Gene expression analysis of A. parasiticus grown under conditions conducive and nonconductive for aflatoxin production was evaluated using glass slide microarrays containing the 753 ESTs. A complex regulatory network governs the biosynthesis of aflatoxin. While several genes involved in aflatoxin ...
ORGANISM(S): Aspergillus parasiticus 
2003-01-15 | E-GEOD-204 | biostudies-arrayexpress
TranscriptomicsEarly target genes of aflatoxin B1 in human hepatic cells
Comparison of gene expression profiles induced by the mycotoxin, aflatoxin B1 (AFB1), in primary human hepatocytes and HepaRG cells. Initial mechanisms involved in the complex multistep process leading to malignant transformation by chemicals remain largely unknown. We have analysed changes in gene ...
ORGANISM(S): Homo sapiens 
2010-12-07 | E-GEOD-25844 | biostudies-arrayexpress
TranscriptomicsEvaluating microRNA profiles reveals discriminative responses following genotoxic or non-genotoxic carcinogen exposure in primary mouse hepatocytes [Affymetrix]
The study investigated differential gene expression in primary mouse hepatocyte mRNA following 24 and 48 hours of exposure to aflatoxin B1, cisplatin, benzo(a)pyrene, 2,3,7,8-tetrachloordibenzo-p-dioxine, cyclosporin A or Wy-14,643 or their responsive solvent. Three (four for Wy-14,643) biological ...
ORGANISM(S): Mus musculus 
2015-05-18 | E-GEOD-57129 | biostudies-arrayexpress
TranscriptomicsEvaluating microRNA profiles reveals discriminative responses following genotoxic or non-genotoxic carcinogen exposure in primary mouse hepatocytes [Exiqon]
The study investigated differential miRNA changes in primary mouse hepatocyte following 24 and 48 hours of exposure to aflatoxin B1, cisplatin, benzo(a)pyrene, 2,3,7,8-tetrachloordibenzo-p-dioxine, cyclosporin A or Wy-14,643 or their responsive solvent. Three (four for Wy-14,643) biological replica...
ORGANISM(S): Mus musculus 
2015-05-18 | E-GEOD-57082 | biostudies-arrayexpress
TranscriptomicsTempo-Seq targeted RNA sequencing of the HepaRG cell line treated with aflatoxin B1, benzo[a]pyrene, cyclosporin A, rotenone and thrichostatin A over a range of chemical concentrations and exposure time points
The experiment investigates the effects of five well-known chemicals on the transcriptome of the HepaRG cell line, a metabolically competent hepatic cell line. The cells were treated individually with an increasing concentrations of aflatoxin B1, benzo[a]pyrene, cyclosporine A, rotenone or trichost...
ORGANISM(S): Homo sapiens 
2023-08-01 | E-MTAB-13168 | biostudies-arrayexpress
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