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ProteomicsThe type VII secretion system protects Staphylococcus aureus against host-specific fatty acids
The Staphylococcus aureus type VII secretion system (T7SS) exports several proteins that are pivotal for bacterial virulence. The mechanisms underlying T7SS-mediated staphylococcal survival during infection are nevertheless unclear. Here we show that EsxC, a small secreted effector implicated in bac...
ORGANISM(S): Staphylococcus aureus 
2021-09-08 | PXD013081 | Pride
Type vii secretion system Staphylococcus aureus Long-chain unsaturated free fatty acids 
TranscriptomicsBacteroides (Phocaeicola)-driven metabolic remodelling suppresses Clostridioides difficile toxin expression in mixed biofilm communities
The aim of this study was to investigate transcriptomic changes in Clostridioides difficile when cultured as monoculture biofilms or as co-culture biofilms with either Bacteroides (Phocaeicola) dorei or Bacteroides (Phocaeicola) vulgatus. This study was also interested in transcriptomic changes occu...
ORGANISM(S): Phocaeicola vulgatus 
2026-09-23 | E-MTAB-15641 | biostudies-arrayexpress
ProteomicsBacteroides-driven metabolic remodelling suppresses Clostridioides difficile toxin expression in mixed biofilm communities
Clostridioides difficile is a major cause of hospital-associated diarrhoea worldwide. The intricate interactions between C. difficile and the resident gut microbiota play a crucial role in determining the outcome of C. difficile infection (CDI), although the molecular mechanisms underlying many C. d...
ORGANISM(S): Phocaeicola dorei CL02T00C15 
2026-10-15 | PXD068536 | Pride
Bacteroides Warwick_rtp Clostridioides difficile Microbiota Stickland fermentation Toxin a Biofilm 
TranscriptomicsTitered FOXO overexpression maintains cardiac proteostasis and ameliorates age-associated functional decline
Heart performance declines with age. Reduced protein quality control (PQC) due to decreased function of the ubiquitin/proteasome system (UPS), autophagy, and/or chaperone-mediated protein refolding is a likely contributor to age-associated cardiac performance decline. The transcription factor FOXO p...
ORGANISM(S): Drosophila melanogaster 
2016-07-01 | E-GEOD-73205 | biostudies-arrayexpress
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