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ProteomicsA novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium
Mitosis in eukaryotes involves reorganization of the nuclear envelope (NE) and microtubule-organizing centres (MTOCs). During male gametogenesis in Plasmodium, the causative agent of malaria, mitosis is exceptionally rapid and highly divergent. Within 8 min, the haploid male gametocyte genome underg...
ORGANISM(S): Plasmodium berghei ANKA 
2025-05-19 | PXD062729 | Pride
Warwick_rtp 
ProteomicsMetaexoproteomics identifies active plant-microbe interactions operating in the rhizosphere - part2
Advances in DNA sequencing technologies has drastically changed our perception of the structure and complexity of the plant microbiome. By comparison, our ability to accurately identify the metabolically active fraction of soil microbiota and its specific functional role in augmenting plant health i...
ORGANISM(S): Pseudomonas putida (strain BIRD-1) 
2022-07-01 | PXD033802 | Pride
Metaproteomics Warwick_rtp 
ProteomicsMetaexoproteomics identifies active plant-microbe interactions operating in the rhizosphere - part3
Advances in DNA sequencing technologies has drastically changed our perception of the structure and complexity of the plant microbiome. By comparison, our ability to accurately identify the metabolically active fraction of soil microbiota and its specific functional role in augmenting plant health i...
ORGANISM(S): Brassica napus (Rape) 
2022-07-01 | PXD033803 | Pride
Metaproteomics Warwick_rtp 
ProteomicsPlasmodium NEK1 coordinates MTOC organisation and kinetochore attachment during rapid mitosis in male gamete formation
Mitosis is an important process in the cell cycle required for cells to divide. Never in mitosis (NIMA)-like kinases (NEKs) are regulators of mitotic functions in diverse organisms. Plasmodium spp, the causative agent of malaria is a divergent unicellular haploid eukaryote with some unusual features...
ORGANISM(S): Plasmodium berghei ANKA 
2024-08-08 | PXD053559 | Pride
Plasmodium Warwick_rtp Nek1 
ProteomicsCdk1-mediated threonine phosphorylation of Sam68 modulates its RNA binding, alternative splicing activity, and cellular functions
Sam68 is a member of the STAR family of proteins that directly link signal transduction with post-transcriptional gene regulation. Sam68 controls the alternative splicing of many oncogenic proteins and its role is modulated by post-translational modifications, including serine/threonine phosphorylat...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD032716 | Pride
Warwick_rtp  sam68  khdrbs1 
ProteomicsHemicellulose utilisation in Flavobacterium
The plant hemicellulose xyloglucan (XyG) is secreted from the roots of numerous plant species, including cereals, and contributes towards soil aggregate formation in terrestrial systems. Whether XyG represents a key nutrient for plant-associated bacteria is unclear. The phylum Bacteroidota are abund...
ORGANISM(S): Flavobacterium sp. F52 
2025-05-07 | PXD053370 | Pride
Flavobacterium Warwick_rtp Hemicellulose Xyloglucan 
ProteomicsNagA mediates the recycling of peptidoglycan derived amino sugars in mycobacteria
Many bacterial species are known to recover peptidoglycan (PG) fragments released from remodelling of their cell walls during growth and cell division. These PG fragments not only provide an essential energy resource, especially in nutrient restricted environments, but also play a critical role in i...
ORGANISM(S): Mycobacterium smegmatis 
2025-11-24 | PXD065120 | Pride
Warwick_rtp Peptidoglycan Naga Mycobacteria 
ProteomicsPlasmodium ARK2 and EB1 drives the unconventional spindle dynamics, during chromosome segregation in sexual transmission stages
The Aurora family of kinases orchestrates chromosome segregation and cytokinesis during cell division, with precise spatiotemporal regulation of its catalytic activities by distinct protein scaffolds. Plasmodium spp., the causative agents of malaria, are unicellular eukaryotes with three unique and ...
ORGANISM(S): Plasmodium berghei ANKA 
2023-08-15 | PXD043164 | Pride
Plasmodium Warwick_rtp Ark2 Eb1 
ProteomicsMetaexoproteomics identifies active plant-microbe interactions operating in the rhizosphere
Advances in DNA sequencing technologies has drastically changed our perception of the structure and complexity of the plant microbiome. By comparison, our ability to accurately identify the metabolically active fraction of soil microbiota and its specific functional role in augmenting plant health i...
ORGANISM(S): soil metagenome 
2022-07-01 | PXD033692 | Pride
Warwick_rtp Metaexoproteomics Lc-ms/ms 
ProteomicsDivergent Plasmodium kinases drive MTOC, kinetochore and axoneme organisation in male gametogenesis
Sexual development and male gamete formation of the malaria parasite in the mosquito midgut is initiated by rapid endomitosis in the activated male gametocyte. This process is highly regulated by protein phosphorylation, specifically by three divergent male-specific protein kinases (PKs): CDPK4, SRP...
ORGANISM(S): Plasmodium berghei ANKA 
2025-03-18 | PXD061651 | Pride
Plasmodium Warwick_rtp Axoneme Mtoc Gametogenesis Kinetochore Kinase 
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