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ProteomicsDivergent Plasmodium kinases drive MTOC, kinetochore and axoneme organisation in male gametogenesis
Sexual development and male gamete formation of the malaria parasite in the mosquito midgut is initiated by rapid endomitosis in the activated male gametocyte. This process is highly regulated by protein phosphorylation, specifically by three divergent male-specific protein kinases (PKs): CDPK4, SRP...
ORGANISM(S): Plasmodium berghei ANKA 
2025-03-18 | PXD061651 | Pride
Plasmodium Warwick_rtp Axoneme Mtoc Gametogenesis Kinetochore Kinase 
ProteomicsA novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium
Mitosis in eukaryotes involves reorganization of the nuclear envelope (NE) and microtubule-organizing centres (MTOCs). During male gametogenesis in Plasmodium, the causative agent of malaria, mitosis is exceptionally rapid and highly divergent. Within 8 min, the haploid male gametocyte genome underg...
ORGANISM(S): Plasmodium berghei ANKA 
2025-05-19 | PXD062729 | Pride
Warwick_rtp 
UnknownPrevention effect of rare ginsenosides against stress-hormone induced MTOC amplification.
Not available
S-EPMC5085216 | biostudies-literature
ProteomicsPlasmodium NEK1 coordinates MTOC organisation and kinetochore attachment during rapid mitosis in male gamete formation
Mitosis is an important process in the cell cycle required for cells to divide. Never in mitosis (NIMA)-like kinases (NEKs) are regulators of mitotic functions in diverse organisms. Plasmodium spp, the causative agent of malaria is a divergent unicellular haploid eukaryote with some unusual features...
ORGANISM(S): Plasmodium berghei ANKA 
2024-08-08 | PXD053559 | Pride
Plasmodium Warwick_rtp Nek1 
UnknownNE-MTOC Formation in Skeletal Muscle Is Mbnl2-Dependent and Occurs in a Sequential and Gradual Manner.
Not available
S-EPMC11853192 | biostudies-literature
UnknownPEDF regulates plasticity of a novel lipid-MTOC axis in prostate cancer-associated fibroblasts.
Not available
S-EPMC6051346 | biostudies-literature
UnknownRapid lytic granule convergence to the MTOC in natural killer cells is dependent on dynein but not cytolytic commitment.
Not available
S-EPMC2893988 | biostudies-literature
UnknownStable kinetochore-microtubule attachments restrict MTOC position and spindle elongation in oocytes.
Not available
S-EPMC8024892 | biostudies-literature
UnknownDGAT1 Inhibitor Suppresses Prostate Tumor Growth and Migration by Regulating Intracellular Lipids and Non-Centrosomal MTOC Protein GM130.
Not available
S-EPMC6395665 | biostudies-literature
UnknownCLIP-170 is essential for MTOC repositioning during T cell activation by regulating dynein localisation on the cell surface.
Not available
S-EPMC6261991 | biostudies-literature
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