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TranscriptomicsAT13148 is a novel, oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity
Purpose: Deregulated phosphatidylinositol 3-kinase pathway signaling through AGC kinases including AKT, p70S6 kinase, PKA, SGK and Rho kinase, is a key driver of multiple cancers. The simultaneous inhibition of multiple AGC kinases may increase antitumor activity and minimize clinical resistance com...
ORGANISM(S): Homo sapiens 
2012-07-19 | E-GEOD-38008 | biostudies-arrayexpress
MetabolomicsCell type-specific proteomics uncovers a RAF15-SnRK2.6/OST1 kinase cascade in guard cells

Multicellular organisms such as plants contain various cell types with specialized functions. Analyzing the characteristics of each cell type reveals specific cell functions and enhances our understanding of organization and function at the organismal level. Guard cells (GCs) are specialized epid...

2024-09-03 | MTBLS3997 | MetaboLights
ProteomicsIn Cellulo Kinase Screen Identifies Novel MASTL Substrates
MASTL (microtubule-associated serine/threonine kinase-like) has emerged as a critical regulator of mitosis and as a potential oncogene in a variety of cancer types. To date, Arpp-19/ENSA are the only known substrates of MASTL. With the cellular roles of MASTL expanding and increased interest in deve...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD028678 | Pride
Akt Phospho-peptides Silac Agc kinase Kinase Mastl 
TranscriptomicsAT13148 is a novel, oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity
Purpose: Deregulated phosphatidylinositol 3-kinase pathway signaling through AGC kinases including AKT, p70S6 kinase, PKA, SGK and Rho kinase, is a key driver of multiple cancers. The simultaneous inhibition of multiple AGC kinases may increase antitumor activity and minimize clinical resistance com...
ORGANISM(S): Homo sapiens 
2012-07-20 | GSE38008 | GEO
TranscriptomicsNKT, CD1d-aGC+ Va24-, and CD4 T cell clones from human peripheral blood
Microarray analysis was performed to determine the transcriptional profiles of NKT, CD1d-aGC+ Va24-, and CD4 T cells. Clones of NKT, CD1d-aGC+ Va24-, and CD4 T cells were generated using peripheral blood drawn from two healthy individuals. RNA was extracted from cells that had been either rested (1...
ORGANISM(S): Homo sapiens 
2011-04-22 | E-GEOD-28726 | biostudies-arrayexpress
UnknownUncoupling TORC2 from AGC kinases inhibits tumour growth.
Not available
S-EPMC5689566 | biostudies-literature
UnknownTesting the promiscuity of commercial kinase inhibitors against the AGC kinase group using a split-luciferase screen.
Not available
S-EPMC3328412 | biostudies-literature
UnknownThe AGC Kinase SsAgc1 Regulates Sporisorium scitamineum Mating/Filamentation and Pathogenicity.
Not available
S-EPMC6541736 | biostudies-literature
UnknownAdi3 is a Pdk1-interacting AGC kinase that negatively regulates plant cell death.
Not available
S-EPMC1356353 | biostudies-literature
TranscriptomicsWheat: Control vs. Pathogen-infected
Differentially expressed kinase genes in Rhizoctonia cerealis resistant wheat lines CI12633/Shanhongmai compared with the susceptible wheat line Wenmai 6 via Agilent Wheat Gene Expression Microarray assay. Goal was to identify the kinase genes whose expression was higher in CI12633/Shanhongmai compa...
ORGANISM(S): Triticum aestivum 
2015-08-06 | E-GEOD-69245 | biostudies-arrayexpress
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