Ageing - OmicsDI

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Unknown (17640)
Transcriptomics (1663)
Genomics (1448)
Proteomics (414)
Models (58)
Methylation profiling (55)
Metabolomics (38)
Other (34)
Clinical (9)
Genomic (2)
Multiomics (1)

Organisms

Homo sapiens (752)
Mus musculus (733)
Caenorhabditis elegans (99)
Drosophila melanogaster (70)
Rattus norvegicus (68)
Arabidopsis thaliana (50)
Saccharomyces cerevisiae (48)
Nothobranchius furzeri (43)
Oryza sativa (12)
Canis lupus familiaris (9)
Schizosaccharomyces pombe (8)
Bos taurus (7)
Macaca mulatta (6)
Heterocephalus glaber (5)
Zea mays (4)
Eukaryota (3)
Hordeum vulgare (3)
Anopheles gambiae (3)
Mammalia (2)
Aplysia californica (2)
Harpegnathos saltator (2)
Saccharomyces pastorianus (2)
Brassica napus (2)
Medicago truncatula (2)
Glycine max (2)
Oryza sativa Japonica Group (2)
Triticum aestivum (2)
Chordata (1)
cellular organisms (1)
Rattus (1)

Organisms

Mus musculus (366)
Homo sapiens (238)
Caenorhabditis elegans (70)
Nothobranchius furzeri (43)
Drosophila melanogaster (40)
Danio rerio (26)
Rattus norvegicus (20)
Saccharomyces cerevisiae (15)
Bos taurus (7)
Arabidopsis thaliana (4)
human gut metagenome (4)
mouse gut metagenome (4)
Heterocephalus glaber (3)
Canis lupus familiaris (3)
Schizosaccharomyces pombe (2)
unidentified (2)
Oncorhynchus mykiss (2)
Oryza sativa (2)
Crepidium acuminatum (1)
Chelonoidis abingdonii (1)
Reticulitermes labralis (1)
Macrostomum lignano (1)
Reticulitermes chinensis (1)
Phyllostomus hastatus (1)
Formica exsecta (1)
Cynops pyrrhogaster (1)
Cynara cardunculus (1)
Paramecium tetraurelia (1)
Pristionchus pacificus (1)
Rattus rattus (1)

Repository

ENA (1252)
biostudies-arrayexpress (1173)
geo (717)
pride (339)
BioModels (56)
EGA (48)
MassIVE (39)
MetaboLights (37)
iProX (21)
jPOST (14)
ExpressionAtlas (5)
GPMDB (5)
dbGaP (2)
FAIRDOMHub (2)
EVA (1)
GNPS (1)
PanoramaPublic (1)

Tissue

Cell culture (58)
Brain (41)
Heart (20)
Whole body (19)
Liver (13)
Epithelial cell (11)
Skeletal muscle (10)
Tendon (10)
Fibroblast of lung (8)
Bone marrow (8)
Fibroblast (8)
Skin (7)
Multipotent stem cell (7)
Neuron (6)
Blood plasma (6)
Stem cell (6)
Kidney (6)
HEK-293 cell (5)
Primary cell (5)
Lung (5)
Permanent cell line cell (5)
Intervertebral disc (4)
Embryonic stem cell (4)
Muscle (4)
Spleen (4)
Hippocampus (3)
Fat body (3)
Keratinocyte (3)
Cerebellum (2)
Cortex (1)

Disease

Alzheimer's disease (13)
Disease free (8)
Not Available (5)
Normal (4)
Colorectal Neoplasms (4)
Neurodegenerative disease (3)
Colon cancer (3)
Rheumatoid arthritis (2)
Parkinson's disease (2)
Osteoarthritis (2)
B-cell lymphoma (2)
Cartilage disease (1)
Cataract (1)
Cholesterol ester storage disease (1)
Diabetes mellitus (1)
Adenocarcinoma (1)
Prostate Cancer (Post Prostatectomy) (1)
Cancer, older patients, ageing, eHealth, patient-provider interaction, communication.Kanker, ouderen, patient-zorgverlener interactie, communicatie (1)
Crohn Disease (1)
Prostatic Neoplasms (1)
Colorectal cancer (1)
Neurilemmomatosis (1)
Neurodevelopmental delay (1)
Bone disease (1)
Epidermolysis bullosa simplex (1)
Plantar fascial fibromatosis (1)
Subjective cognitive decline (1)
Neurodegeneration (1)
Cardiomyopathy (1)
Connective tissue disease (1)

Technology Type

Mass Spectrometry (339)
Shotgun proteomics (212)
Bottom-up proteomics (63)
Data-independent acquisition (35)
Data-dependent acquisition (27)
SWATH MS (20)
Mass spectrometry (19)
NMR spectroscopy (12)
Affinity purification coupled with mass spectrometry proteomics (11)
Gel-based experiment (8)
Top-down proteomics (7)
Mass spectrometry assay (5)
DiaPASEF (3)
SRM/MRM (3)
Chemical cross-linking coupled with mass spectrometry proteomics (2)
COMPLETE_GENOMICS, Complete Genomics (1)
MeDIP-seq (1)
NMR spectroscopy assay (1)
Affinity proteomics (1)
All-ion fragmentation (1)
HDMSE (1)

Instrument Platform

Illumina HiSeq 2500 (28)
Illumina NovaSeq 6000 (27)
NextSeq 500 (23)
Illumina HiSeq 2000 (16)
Illumina HiSeq 4000 (15)
NextSeq 2000 (5)
NextSeq 550 (5)
Illumina HiSeq 3000 (4)
Illumina NovaSeq X (3)
- (3)
Controlled-environment growth chamber (short-day; 8 h light / 16 h dark) (2)
ScanArray Express HT [PerkinElmer] (2)
Scanning hardware (2)
Illumina HiSeq 1500 (2)
Qiagen RNEasy Mini ki (1)
BD FACSAriaIIu cell sorter (1)
Poly-T oligo-attached magnetic beads (1)
10X Genomics Chromium Single Cell Kit (1)
Covaris sonicator, PCR thermocycler, magnetic rack for SPRI bead clean-up (1)
Liquid-nitrogen mortar and pestle, benchtop microcentrifuge, vortex mixer (1)
Dissecting tools, liquid nitrogen, −80 °C freezer (1)
Thermocycler; magnetic rack for SPRI bead clean-up (1)
Liquid-nitrogen grinding tools; benchtop centrifuge (1)
Illumina HiSeq2500 (1)
Covaris, NEBNext Ultra II DNA library prep kit (1)
MoFlo XPD (Beckman Coulter, Fullerton, CA, USA) flow cytometer (1)
FACS Aria II (1)
Illumina HiSeq (1)
Illumina iScan (1)
Affymetrix GeneChip(R) HT Scanner (1)

Publication Date

2021 (214)
2015 (191)
2024 (182)
2014 (180)
2013 (158)
2023 (156)
2025 (148)
2016 (124)
2026 (124)
2011 (114)
2010 (113)
2012 (111)
2022 (108)
2020 (89)
2018 (83)
2019 (73)
2008 (67)
2017 (58)
2009 (38)
2007 (27)
2006 (10)
2005 (7)
2004 (4)
2003 (3)

UNIPROT ID/AC

Q13315 (6)
P04637 (6)
Q00987 (6)
P62136 (3)
P05067 (3)
P49841 (3)
P45983 (3)
Q16539 (3)
P31749 (3)
P01583 (2)
P45452 (2)
P02458 (2)
Q6A4J8 (2)
P62878 (2)
Q923E4 (2)
P97769 (2)
Q76MZ3 (2)
Q9ESN9 (2)
Q9R0T8 (2)
Q91WG5 (2)
Q9WVC6 (2)
P31750 (2)
Q9R1E0 (2)
Q13950 (2)
P0CG47 (2)
P38936 (2)
Q61501 (2)
P97377 (2)
Q07812 (2)
P10415 (2)

ENSEMBL ID

ENSG00000141510 (2)
ENSG00000135679 (2)
ENSG00000100234 (1)
ENSG00000102265 (1)
ENSG00000184557 (1)
ENSG00000137745 (1)
ENSG00000196611 (1)
ENSG00000177606 (1)
ENSG00000170345 (1)
ENSG00000158859 (1)
ENSG00000149968 (1)
ENSG00000147889 (1)

CHEBI ID

CHEBI:15422 (16)
CHEBI:16761 (16)
CHEBI:30769 (16)
CHEBI:16027 (15)
CHEBI:15428 (14)
CHEBI:32816 (14)
CHEBI:16737 (14)
CHEBI:16414 (12)
CHEBI:15891 (12)
CHEBI:26523 (11)
CHEBI:16856 (10)
CHEBI:16991 (8)
CHEBI:17858 (7)
CHEBI:16113 (5)
CHEBI:67079 (2)
CHEBI:33697 (2)
CHEBI:36080 (2)
CHEBI:33699 (2)
CHEBI:37328 (1)
CHEBI:60169 (1)
CHEBI:4705 (1)
CHEBI:61995 (1)
CHEBI:22868 (1)
CHEBI:64645 (1)
CHEBI:33709 (1)
CHEBI:5931 (1)
CHEBI:17002 (1)
CHEBI:9160 (1)
CHEBI:09160 (1)
CHEBI:17984 (1)

Metabolite Name

Creatinine (11)
L-Histidine (11)
Glycine (10)
Creatine (10)
L-Phenylalanine (10)
L-Threonine (10)
L-Valine (10)
L-Tyrosine (9)
L-Glutamine (9)
L-Alanine (9)
L-Isoleucine (9)
Adenosine (8)
Taurine (8)
Choline (8)
Xanthine (8)
Betaine (7)
Adenine (7)
D-Glucose (7)
ADP (7)
L-Proline (7)
Glycerol (7)
Phosphorylcholine (7)
L-Asparagine (7)
L-Methionine (7)
L-Lysine (7)
L-Leucine (7)
Ethanol (6)
L-Lactic acid (6)
Pyruvic acid (6)
Guanidoacetic acid (6)

First Public Date

2021 (188)
2024 (156)
2023 (150)
2025 (120)
2026 (119)
2022 (96)
2014 (77)
2018 (75)
2020 (69)
2019 (61)
2015 (49)
2017 (40)
2016 (26)
2013 (26)

Modelling Approach

Ordinary differential equation model (51)
Mathematical model (1)
Other (1)

Study status

Completed (4)
Active, not recruiting (2)
Recruiting (2)
Not provided (1)

Lab affiliation

Max-Planck-Institute for Biology of Ageing Department of Mitochondrial Proteostasis Joseph-Stelzmann-Str. 9b 50931 Cologne (14)
Institute of Molecular Biology (IMB), 55128 Mainz, Germany; Institute of Developmental Biology and Neurobiology (IDN), Johannes Gutenberg University, 55128 Mainz, Germany (7)
Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA (6)
Laboratoire de Spectrométrie de Masse BioOrganique, Analytical Science department, IPHC, CNRS, Strasbourg University, UMR7178, Strasbourg, France (6)
Max-Planck-Institute for Biology of Ageing Department of Mitochondrial Proteostasis Joseph-Stelzmann-Str. 9b 50931 Cologne Germany (6)
CECAD, University of Cologne (6)
Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) Beutenbergstraße 11 07745 Jena, Germany (4)
Leibniz Institute on Aging, Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany (4)
University of Liverpool (4)
1. Center for Molecular Medicine Cologne, University of Cologne, Robert-Koch-Str. 21, D- 50931 Cologne, Germany 2. Inst. for Neurophysiology, University of Cologne, Robert-Koch-Str. 39, D-50931 Cologne, Germany 3. CECAD; Cologne Cluster of Excellence in Cellular Stress Responses in Ageing-associated Diseases, University of Cologne, Joseph-Stelzmann-Str. 26, D-50931 Cologne, Germany (3)
Division of Cell Matrix Biology & Regenerative Medicine (L5) / Division of Cell Matrix Biology & Regenerative Medicine, University of Manchester (3)
Max-Planck-Institute for Biology of Ageing Joseph-Stelzmann-Str. 9b 50931 Cologne, Germany (3)
The University of Manchester (3)
Max-Planck-Institute for Biology of Ageing Department of Mitochondrial Proteostasis Joseph-Stelzmann-Str. 9b 50931 Cologne, Germany (2)
Molecular Evolution, Department of Cell and Molecular Biology, Science for Life Laboratory, Biomedical Centre, Uppsala University, SE-751 24 Uppsala, Sweden (2)
Human Phenome Institute,Zhangjiang FudanInternational Innovation Center, Fudan UniversityShanghai, 201203, China. (2)
Ori Research Group, The Leibniz Institute on Aging – Fritz Lipmann Institute, Jena, Germany (2)
Laboratory of Ageing and Pharmacology, Kolling Institute, The University of Sydney (2)
Institute of Ageing and Chronic Disease, University of Liverpool, United Kingdom (2)
State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, Hubei,China (2)
University of Modena and Reggio Emilia (2)
School of Biomedical Sciences, The University of Hong Kong (2)
Head, Chair Plant Biotechnology Faculty of Biology University of Freiburg Schaenzlestrasse 1 D-79104 Freiburg Germany (2)
National Key Laboratory of Medical Molecular Biology & Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (2)
Department of Medical Biotechnology Faculty of Biochemistry, Biophysics and Biotechnology Jagiellonian University Gronostajowa 7 30-387 Krakow, Poland (2)
Department of Mitochondrial Proteostasis Joseph-Stelzmann-Str. 9b 50931 Cologne (1)
Leibniz Institute for Aging - Fritz-Lipmann-Institut (FLI) Beutenbergstraße 11 07745 Jena (1)
Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW, 2052, Australia (1)
Cambridge Centre for Proteomics University of Cambridge (1)
Institute of Ageing and Chronic Disease, Musculoskeletal Biology I University of Liverpool UK (1)

Keyword

Lycopene (1)
Anti EGFR therapy (1)
Cancer risk (1)
Testosterone (1)
Frailty (1)
Biomarkers (1)
Cancer prevention (1)
Prostate (1)
Head and Neck (1)
Anal (1)
Diet (1)
Pharmacokinetics (1)
Capecitabine (1)

IsPrivate

False (56)

Model Flag

Non Kinetic (2)

Modification

N6 (1)

Study type

Transcription profiling by array (751)
RNA-seq of coding RNA (150)
Methylation profiling by array (66)
ChIP-seq (41)
Unknown experiment type (25)
RNA-seq of non coding RNA (23)
RNA-seq of coding RNA from single cells (16)
Methylation profiling by high throughput sequencing (14)
ChIP-chip by array (9)
Comparative genomic hybridization by array (8)
Animal - One-color microarray (6)
Cell line - High-throughput sequencing (6)
Other (5)
DNA-seq (5)
ChIP-chip by tiling array (4)
Animal - High-throughput sequencing (4)
Transcription profiling by RT-PCR (4)
RNA-seq of total RNA (4)
RNAi profiling by array (3)
Bisulfite-seq (3)
Transcription profiling by SAGE (2)
Two-color microarray (2)
Human - Methylation microarray (2)
Plant - High-throughput sequencing (2)
High-throughput sequencing (2)
RIP-seq (2)
Single nucleus RNA sequencing (2)
MicroRNA profiling by array (2)
Cell line - Methylation microarray (1)
Animal - Two-color microarray (1)

Release Date

2025 (2239)
2022 (2182)
2023 (2012)
2021 (1918)
2024 (1691)
2020 (1545)
2019 (1280)
2018 (1061)
2017 (885)
2016 (796)
2015 (755)
2014 (622)
2013 (404)
2026 (312)
2012 (306)
2011 (243)
2010 (217)
2008 (112)
2009 (100)
2007 (60)
2006 (29)
2005 (18)
2004 (9)
2003 (8)
2002 (3)
2001 (2)
1999 (1)

Location

Australia (2)
United Kingdom (2)
New Zealand (1)
Netherlands (1)
Italy (1)

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1H NMR metabolomics and lipidomics analysis of neutrophils reveals biomarkers of ageing, inflammageing and frailty

Neutrophil function declines with age, but little is known about the changes in neutrophil metabolism that take place in robust older people and older people with frailty. We used ¹H-NMR spectroscopy to investigate the metabolomic and lipidomic profiles of blood neutrophils from healthy y...

2026-03-26 | MTBLS6055 | MetaboLights

Metabolic Biomarkers of Ageing in C57BL/6J Wild-Type and Flavin-Containing Monooxygenase 5 (FMO5)-Knockout Mice

It was recently demonstrated in mice that knockout of the flavin-containing monooxygenase 5 gene, Fmo5, slows metabolic ageing via pleiotropic effects. We have now used an NMR-based metabonomics approach to study the effects of ageing directly on the metabolic profiles of urine and plasma from male,...

2018-06-20 | MTBLS667 | MetaboLights

The Leiden Longevity Study: Identification of biomarkers of the rate of ageing

The aim of the study is to identify genetic mechanisms of longevity and to characterize their interaction with the environment. Using the results the future health of people without familial longevity can be improved in old age. Long-lived siblings of European descent were recruited together with th...

2019-07-11 | MTBLS974 | MetaboLights

Expression data from control, aged and activated neutrophils in mouse blood

Neutrophils provide immune protection against pathogens but also may promote tissue injury in inflammatory diseases. Although neutrophils are generally considered as a relatively homogeneous population, evidence for heterogeneity is emerging. Under steady-state conditions, neutrophil heterogeneity m...

ORGANISM(S): Mus musculus

2015-09-24 | E-GEOD-69886 | biostudies-arrayexpress

MicroRNA-34a regulates cardiac ageing and function

We compared the heart of 6-weeks-old mice (young) with 18-months-old mice (old) hearts of 6 week old and 18 month old mice

ORGANISM(S): Mus musculus

2013-02-20 | E-GEOD-43556 | biostudies-arrayexpress

Ageing-associated changes in the expression of lncRNAs in human tissues reflect a transcriptional modulation in ageing pathways.

Not available

S-EPMC6961210 | biostudies-literature

The Functional and Anatomical Impacts of Healthy Muscle Ageing.

Not available

S-EPMC10604714 | biostudies-literature